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- W2024854598 abstract "In recent years, there have been numerous reports addressing the relationship between sleep-disordered breathing (SDB) and hypertension (HTN). This study investigated the relationship between SDB and BP after controlling for age, gross obesity, and notably, antihypertensive medications. Sixty-seven men and women between 30 and 60 years of age and between 0.90 to 1.5 times ideal body weight were studied. SDB was assessed over two nights of polysomnographic monitoring, and BP was measured over repeated visits to the hospital. The results indicate that respiratory disturbance index (BDI) independently predicts diastolic BP (DBP), accounting for 15% of the variance in DBP (p=0.02). In subjects with severe levels of SDB (RDI >30), RDI uniquely accounted for 36% of the variance in DBP (p=0.003). Interestingly, SDB was not independently related to systolic BP. The physiologic mechanisms responsible for these findings are currently being explored. In recent years, there have been numerous reports addressing the relationship between sleep-disordered breathing (SDB) and hypertension (HTN). This study investigated the relationship between SDB and BP after controlling for age, gross obesity, and notably, antihypertensive medications. Sixty-seven men and women between 30 and 60 years of age and between 0.90 to 1.5 times ideal body weight were studied. SDB was assessed over two nights of polysomnographic monitoring, and BP was measured over repeated visits to the hospital. The results indicate that respiratory disturbance index (BDI) independently predicts diastolic BP (DBP), accounting for 15% of the variance in DBP (p=0.02). In subjects with severe levels of SDB (RDI >30), RDI uniquely accounted for 36% of the variance in DBP (p=0.003). Interestingly, SDB was not independently related to systolic BP. The physiologic mechanisms responsible for these findings are currently being explored. Hypertension and OSA: Silent Bedpartners?CHESTVol. 109Issue 4PreviewThere is an abundance of literature investigating the possible relationship between obstructive sleep apnea (OSA) and hypertension. OSA is thought to afflict from 2 to 10% of the adult population, and hypertension is found in up to 20%. Besides OSA and hypertension being common illnesses, other factors confound this possible relationship, including an increased incidence with aging, obesity, and male sex. Furthermore, antihypertensive medications may change the severity of OSA. Both OSA and hypertension are silent—often the afflicted are unaware of their presence. Full-Text PDF" @default.
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- W2024854598 title "The Role of Sleep-Disordered Breathing in Essential Hypertension" @default.
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- W2024854598 doi "https://doi.org/10.1378/chest.109.4.890" @default.
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