Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024854985> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2024854985 endingPage "216" @default.
- W2024854985 startingPage "207" @default.
- W2024854985 abstract "Previously, we showed that kappa-selective ligands inhibit adenylyl cyclase in guinea pig cerebellar membranes. The present studies explore the relationship between kappa 1 binding sites (as determined with [3H]U-69,593 binding) and kappa 1-inhibition of adenylyl cyclase (using U-50,488H) in guinea pig brain membranes. Various kappa opioids displaced [3H]U-69,593 binding at a single site with subnanomolar affinities. These agonists were several hundred-fold weaker in inhibiting adenylyl cyclase, but for most agonists the rank order of adenylyl cyclase inhibition paralleled the displacement of kappa 1 binding. The correlation of IC50 values for both adenylyl cyclase and binding was significant except for alpha-neo endorphin, which was relatively weak at inhibiting adenylyl cyclase despite a Ki value of 0.08 nM versus kappa 1 binding. Comparison between kappa 1 binding and kappa 1-inhibited adenylyl cyclase across eleven guinea pig brain regions revealed that kappa 1-inhibited adenylyl cyclase was highest in the cerebellum, absent in thalamus and superior colliculus, and moderate in other regions. In most regions, kappa 1 binding correlated with the efficacy of kappa 1-inhibited adenylyl cyclase. However, the hippocampus had high levels of kappa 1-inhibited adenylyl cyclase despite low levels of kappa 1 binding, while cortex exhibited a high density of kappa 1 sites but a relatively low level of kappa 1-inhibited adenylyl cyclase. Reaction of cerebellar kappa receptors with beta-chlornaltrexamine (beta-CNA) blocked both kappa 1 binding and kappa 1-inhibited adenylyl cyclase. The effect of beta-CNA on kappa 1-inhibited adenylyl cyclase was to inhibit efficacy with little decrease in agonist potency, thus suggesting no significant level of kappa receptor reserve for this effector system." @default.
- W2024854985 created "2016-06-24" @default.
- W2024854985 creator A5033048556 @default.
- W2024854985 creator A5051899832 @default.
- W2024854985 date "1993-01-01" @default.
- W2024854985 modified "2023-10-17" @default.
- W2024854985 title "Relationship between kappa1 opioid receptor binding and inhibition of adenylyl cyclase in guinea pig brain membranes" @default.
- W2024854985 cites W1775749144 @default.
- W2024854985 cites W1963897852 @default.
- W2024854985 cites W1966044513 @default.
- W2024854985 cites W1973198816 @default.
- W2024854985 cites W1974748839 @default.
- W2024854985 cites W1996545479 @default.
- W2024854985 cites W1996650757 @default.
- W2024854985 cites W1996997570 @default.
- W2024854985 cites W2003012589 @default.
- W2024854985 cites W2010531200 @default.
- W2024854985 cites W2013317876 @default.
- W2024854985 cites W2034440616 @default.
- W2024854985 cites W2034563808 @default.
- W2024854985 cites W2040825227 @default.
- W2024854985 cites W2044620302 @default.
- W2024854985 cites W2046435944 @default.
- W2024854985 cites W2058003793 @default.
- W2024854985 cites W2058746796 @default.
- W2024854985 cites W2059512977 @default.
- W2024854985 cites W2064088278 @default.
- W2024854985 cites W2069624989 @default.
- W2024854985 cites W2074522408 @default.
- W2024854985 cites W2074599713 @default.
- W2024854985 cites W2080930955 @default.
- W2024854985 cites W2083084453 @default.
- W2024854985 cites W2090383498 @default.
- W2024854985 cites W2125152850 @default.
- W2024854985 cites W2125752041 @default.
- W2024854985 cites W2160887357 @default.
- W2024854985 doi "https://doi.org/10.1016/0006-2952(93)90394-c" @default.
- W2024854985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8381004" @default.
- W2024854985 hasPublicationYear "1993" @default.
- W2024854985 type Work @default.
- W2024854985 sameAs 2024854985 @default.
- W2024854985 citedByCount "25" @default.
- W2024854985 countsByYear W20248549852013 @default.
- W2024854985 countsByYear W20248549852016 @default.
- W2024854985 countsByYear W20248549852017 @default.
- W2024854985 countsByYear W20248549852019 @default.
- W2024854985 countsByYear W20248549852020 @default.
- W2024854985 countsByYear W20248549852021 @default.
- W2024854985 crossrefType "journal-article" @default.
- W2024854985 hasAuthorship W2024854985A5033048556 @default.
- W2024854985 hasAuthorship W2024854985A5051899832 @default.
- W2024854985 hasConcept C170493617 @default.
- W2024854985 hasConcept C176303035 @default.
- W2024854985 hasConcept C184389661 @default.
- W2024854985 hasConcept C185592680 @default.
- W2024854985 hasConcept C2751546 @default.
- W2024854985 hasConcept C2778938600 @default.
- W2024854985 hasConcept C2779178603 @default.
- W2024854985 hasConcept C2780069284 @default.
- W2024854985 hasConcept C55493867 @default.
- W2024854985 hasConcept C69101867 @default.
- W2024854985 hasConcept C9140185 @default.
- W2024854985 hasConceptScore W2024854985C170493617 @default.
- W2024854985 hasConceptScore W2024854985C176303035 @default.
- W2024854985 hasConceptScore W2024854985C184389661 @default.
- W2024854985 hasConceptScore W2024854985C185592680 @default.
- W2024854985 hasConceptScore W2024854985C2751546 @default.
- W2024854985 hasConceptScore W2024854985C2778938600 @default.
- W2024854985 hasConceptScore W2024854985C2779178603 @default.
- W2024854985 hasConceptScore W2024854985C2780069284 @default.
- W2024854985 hasConceptScore W2024854985C55493867 @default.
- W2024854985 hasConceptScore W2024854985C69101867 @default.
- W2024854985 hasConceptScore W2024854985C9140185 @default.
- W2024854985 hasIssue "1" @default.
- W2024854985 hasLocation W20248549851 @default.
- W2024854985 hasLocation W20248549852 @default.
- W2024854985 hasOpenAccess W2024854985 @default.
- W2024854985 hasPrimaryLocation W20248549851 @default.
- W2024854985 hasRelatedWork W1816979456 @default.
- W2024854985 hasRelatedWork W1979148478 @default.
- W2024854985 hasRelatedWork W1995849084 @default.
- W2024854985 hasRelatedWork W2006725999 @default.
- W2024854985 hasRelatedWork W2014641191 @default.
- W2024854985 hasRelatedWork W2022672771 @default.
- W2024854985 hasRelatedWork W2024854985 @default.
- W2024854985 hasRelatedWork W2078817376 @default.
- W2024854985 hasRelatedWork W2160312562 @default.
- W2024854985 hasRelatedWork W4248254109 @default.
- W2024854985 hasVolume "45" @default.
- W2024854985 isParatext "false" @default.
- W2024854985 isRetracted "false" @default.
- W2024854985 magId "2024854985" @default.
- W2024854985 workType "article" @default.