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- W2024856918 abstract "The diagnosis of male hypogonadism should be clearly established on a clinical and biological basis before considering the initiation of a substitutive treatment with androgens. A careful evaluation of advantages, constraints and limitations of the treatment should be done previously. The potential advantages of an androgenic substitution include an improvement of the symptoms of hypogonadism and the prevention of its bone and metabolic consequences. Absolute (namely prostatic) or relative contraindications should be detected before starting any substitution. The modalities of treatment will be adapted to both the patient's age and the goals to reach. The different available formulations do not induce a similar pattern of plasma testosterone levels. Patches, gel applications and long-acting intramuscular formulations [injected every 3 months] result in stable plasma levels in the physiologic range. The main limitation to their use is linked to a financial aspect as they are not the object of any refund. A careful survey (on clinical, biological and radiological basis) should be established after starting the substitutive treatment with androgens. Une substitution androgénique ne peut être envisagée qu’après avoir affirmé le diagnostic d’hypogonadisme sur des arguments cliniques et biologiques clairs. Une évaluation précise des avantages, contraintes et inconvénients prévisibles du traitement doit être un préalable à toute prescription. Les bénéfices potentiels associent correction des symptômes d’hypogonadisme et prévention de son retentissement, notamment osseux et métabolique. Certaines contre-indications absolues (en particulier prostatiques) ou relatives doivent être dépistées préalablement à toute mise en route d’une substitution par androgènes. Les modalités du traitement doivent être adaptées à l’âge de chaque patient et aux objectifs à atteindre. Les différentes formulations disponibles n’induisent pas le même profil d’évolution de la testostérone plasmatique : patchs, gel et injections trimestrielles permettent d’obtenir des taux stables dans les limites physiologiques. L’inconvénient majeur de ces formulations est d’être à la charge financière totale du patient. Une fois la substitution androgénique instaurée, une surveillance régulière (clinique, biologique et radiologique) doit être assurée." @default.
- W2024856918 created "2016-06-24" @default.
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- W2024856918 date "2014-02-01" @default.
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- W2024856918 title "Traitement androgénique des hypoandrismes masculins" @default.
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