FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024860192> ?p ?o ?g. }

• W2024860192 abstract "Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal, degenerative neuromuscular disease characterized by a progressive loss of voluntary motor activity. About 95% of ALS patients are in sporadic form-meaning their disease is not associated with a family history of the disease. To date, the genetic factors of the sporadic form of ALS are poorly understood. Methods We proposed a two-stage approach based on seventeen biological plausible models to search for two-locus combinations that have significant joint effects to the disease in a genome-wide association study (GWAS). We used a two-stage strategy to reduce the computational burden associated with performing an exhaustive two-locus search across the genome. In the first stage, all SNPs were screened using a single-marker test. In the second stage, all pairs made from the 1000 SNPs with the lowest p-values from the first stage were evaluated under each of the 17 two-locus models. Results we performed the two-stage approach on a GWAS data set of sporadic ALS from the SNP Database at the NINDS Human Genetics Resource Center DNA and Cell Line Repository http://ccr.coriell.org/ninds/ . Our two-locus analysis showed that two two-locus combinations--rs4363506 (SNP1) and rs3733242 (SNP2), and rs4363506 and rs16984239 (SNP3) -- were significantly associated with sporadic ALS. After adjusting for multiple tests and multiple models, the combination of SNP1 and SNP2 had a p-value of 0.032 under the Dom∩Dom epistatic model; SNP1 and SNP3 had a p-value of 0.042 under the Dom × Dom multiplicative model. Conclusion The proposed two-stage analytical method can be used to search for joint effects of genes in GWAS. The two-stage strategy decreased the computational time and the multiple testing burdens associated with GWAS. We have also observed that the loci identified by our two-stage strategy can not be detected by single-locus tests." @default.
• W2024860192 created "2016-06-24" @default.
• W2024860192 creator A5035072440 @default.
• W2024860192 creator A5054390762 @default.
• W2024860192 creator A5056056728 @default.
• W2024860192 creator A5061115409 @default.
• W2024860192 creator A5087260383 @default.
• W2024860192 date "2009-09-09" @default.
• W2024860192 modified "2023-10-10" @default.
• W2024860192 title "Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis" @default.
• W2024860192 cites W1967839356 @default.
• W2024860192 cites W1971144317 @default.
• W2024860192 cites W1981484386 @default.
• W2024860192 cites W1984979116 @default.
• W2024860192 cites W1992002234 @default.
• W2024860192 cites W1997711233 @default.
• W2024860192 cites W1998970893 @default.
• W2024860192 cites W2001657042 @default.
• W2024860192 cites W2012642411 @default.
• W2024860192 cites W2020430676 @default.
• W2024860192 cites W2023556666 @default.
• W2024860192 cites W2027853715 @default.
• W2024860192 cites W2037261873 @default.
• W2024860192 cites W2053272214 @default.
• W2024860192 cites W2053848550 @default.
• W2024860192 cites W2054883878 @default.
• W2024860192 cites W2057289154 @default.
• W2024860192 cites W2076788657 @default.
• W2024860192 cites W2084304698 @default.
• W2024860192 cites W2096386031 @default.
• W2024860192 cites W2098189071 @default.
• W2024860192 cites W2110551795 @default.
• W2024860192 cites W2111803432 @default.
• W2024860192 cites W2114688149 @default.
• W2024860192 cites W2115033587 @default.
• W2024860192 cites W2118259897 @default.
• W2024860192 cites W2120966575 @default.
• W2024860192 cites W2130271153 @default.
• W2024860192 cites W2136681577 @default.
• W2024860192 cites W2143518046 @default.
• W2024860192 cites W2146927915 @default.
• W2024860192 cites W2154572047 @default.
• W2024860192 cites W2157562219 @default.
• W2024860192 cites W2158489424 @default.
• W2024860192 cites W2170108800 @default.
• W2024860192 cites W2921518941 @default.
• W2024860192 doi "https://doi.org/10.1186/1471-2350-10-86" @default.
• W2024860192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2752455" @default.
• W2024860192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19740415" @default.
• W2024860192 hasPublicationYear "2009" @default.
• W2024860192 type Work @default.
• W2024860192 sameAs 2024860192 @default.
• W2024860192 citedByCount "19" @default.
• W2024860192 countsByYear W20248601922012 @default.
• W2024860192 countsByYear W20248601922013 @default.
• W2024860192 countsByYear W20248601922014 @default.
• W2024860192 countsByYear W20248601922016 @default.
• W2024860192 countsByYear W20248601922018 @default.
• W2024860192 countsByYear W20248601922020 @default.
• W2024860192 countsByYear W20248601922021 @default.
• W2024860192 countsByYear W20248601922022 @default.
• W2024860192 countsByYear W20248601922023 @default.
• W2024860192 crossrefType "journal-article" @default.
• W2024860192 hasAuthorship W2024860192A5035072440 @default.
• W2024860192 hasAuthorship W2024860192A5054390762 @default.
• W2024860192 hasAuthorship W2024860192A5056056728 @default.
• W2024860192 hasAuthorship W2024860192A5061115409 @default.
• W2024860192 hasAuthorship W2024860192A5087260383 @default.
• W2024860192 hasBestOaLocation W20248601921 @default.
• W2024860192 hasConcept C104317684 @default.
• W2024860192 hasConcept C106208931 @default.
• W2024860192 hasConcept C119857082 @default.
• W2024860192 hasConcept C135763542 @default.
• W2024860192 hasConcept C139275648 @default.
• W2024860192 hasConcept C142724271 @default.
• W2024860192 hasConcept C153209595 @default.
• W2024860192 hasConcept C186413461 @default.
• W2024860192 hasConcept C2779134260 @default.
• W2024860192 hasConcept C2780596555 @default.
• W2024860192 hasConcept C41008148 @default.
• W2024860192 hasConcept C54355233 @default.
• W2024860192 hasConcept C58041806 @default.
• W2024860192 hasConcept C71924100 @default.
• W2024860192 hasConcept C84597430 @default.
• W2024860192 hasConcept C86803240 @default.
• W2024860192 hasConcept C9357733 @default.
• W2024860192 hasConceptScore W2024860192C104317684 @default.
• W2024860192 hasConceptScore W2024860192C106208931 @default.
• W2024860192 hasConceptScore W2024860192C119857082 @default.
• W2024860192 hasConceptScore W2024860192C135763542 @default.
• W2024860192 hasConceptScore W2024860192C139275648 @default.
• W2024860192 hasConceptScore W2024860192C142724271 @default.
• W2024860192 hasConceptScore W2024860192C153209595 @default.
• W2024860192 hasConceptScore W2024860192C186413461 @default.
• W2024860192 hasConceptScore W2024860192C2779134260 @default.
• W2024860192 hasConceptScore W2024860192C2780596555 @default.
• W2024860192 hasConceptScore W2024860192C41008148 @default.
• W2024860192 hasConceptScore W2024860192C54355233 @default.
• W2024860192 hasConceptScore W2024860192C58041806 @default.
• W2024860192 hasConceptScore W2024860192C71924100 @default.

• next