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- W202486157 abstract "This chapter discusses the increased rate of metabolism of vitamin D 3 in phenobarbiton-induced rats. An initial pilot study showed that the phenobarbitone-treated rats have a greater proportion of peak IV radioactivity in their plasma at both 12 and 24 h after an i.v. dose of vitamin D as compared with control animals. The results that follow relate to the 24-h time period, and each represents the Mean ± Standard Error of the Mean. These results suggest that phenobarbitone administration causes an enhancement of hydroxylation of vitamin D 3 to 25-HCC at 24 h. However, they also show an associated increase in Peak V radioactivity. The results suggest that phenobarbitone administration has no effect on the metabolism of injected 25-HCC in the induced rats. The excess peak V radioactivity previously observed in induced rats after vitamin D was therefore probably due to the normal metabolism of an increased load of 25-HCC. Alternatively, an excess of 25-OH cholecalciferol could be catabolized to inactive metabolites, which might then be excreted." @default.
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- W202486157 date "1972-01-01" @default.
- W202486157 modified "2023-09-25" @default.
- W202486157 title "Increased Rate of Metabolism of Vitamin D3 in Phenobarbitone-Induced Rats" @default.
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- W202486157 doi "https://doi.org/10.1016/b978-0-433-32202-3.50060-2" @default.
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