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• W2024862473 abstract "A 54‐year‐old man maintained on hemodialysis had a relapse of multiple pulmonary metastases after multimodal therapy for primary hepatocellular carcinoma (HCC). He was treated with tegafur‐uracil (UFT; 400 mg/day) and interferon alfa (IFN‐α; 5 × 10 6 units three times per week) for 4 weeks. Following this he was treated with systemic 5‐fluorouracil (5‐FU; 1000 mg/day, 5 days per week) and cisplatin (CDDP; 10 mg/day, 5 days per week for 2 weeks). The response to the above treatments was inadequate; pulmonary metastasis deteriorated. Finally, we selected systemic chemotherapy of 5‐FU (750 mg/day, 5 days per week) and recombinant IFN‐α‐2b (3 × 10 6 units three times per week) for 2 weeks. This therapy resulted in excellent shrinkage of pulmonary metastases, without severe adverse reactions. Hemodialysis was performed three times a week. We report a case of successful treatment of pulmonary metastases by systemic combination chemotherapy of 5‐FU–IFN, previously unsuccessfully treated with UFT–IFN and 5‐FU–CDDP in a patient on hemodialysis. Further studies are needed to select appropriate drugs with fluoropyrimidine‐based systemic chemotherapy, and to analyze the pharmacokinetics of those agents in hemodialysis patients with HCC and extrahepatic metastases." @default.
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• W2024862473 date "2009-03-26" @default.
• W2024862473 modified "2023-10-16" @default.
• W2024862473 title "Successful treatment of pulmonary metastases associated with advanced hepatocellular carcinoma by systemic 5-fluorouracil combined with interferon-α in a hemodialysis patient" @default.
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• W2024862473 doi "https://doi.org/10.1111/j.1872-034x.2008.00448.x" @default.
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