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- W2024862634 abstract "1 The effects of 1,1′-diheptyl-4,4′-bipyridinium dibromide (DHBP), a viologen for electrochromic memory display agent, on calcium release and ryanodine binding were studied with triad-rich sarcoplasmic reticulum (SR) vesicles isolated from rabbit skeletal muscle. 2 DHBP inhibited the calcium release induced by 2 mM caffeine and 2 μg ml−1 polylysine with an IC50 value of 5 μg ml−1 and 4 μg ml−1 respectively. 3 DHBP inhibited [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg ml−1 and 90–100% inhibition at 20–30 μg ml−1. 4 Calcium uptake by SR was inhibited in the presence of caffeine and this inhibition was antagonized by concomitant addition of DHBP. 5 The effect of DHBP on muscle twitches was studied on the mouse diaphragm. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 μm ryanodine were blocked by pretreatment with DHBP. 6 Data from this study provided evidence that DHBP blocked the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor. A possible use of this agent as a specific inhibitor for calcium release and as a muscle relaxant was suggested." @default.
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- W2024862634 date "1994-08-01" @default.
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- W2024862634 title "Effects of bipyridylium compounds on calcium release from triadic vesicles isolated from rabbit skeletal muscle" @default.
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- W2024862634 doi "https://doi.org/10.1111/j.1476-5381.1994.tb13213.x" @default.
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