Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024862945> ?p ?o ?g. }
- W2024862945 endingPage "881" @default.
- W2024862945 startingPage "873" @default.
- W2024862945 abstract "Gelsolin modulates the actin cytoskeleton in the cytoplasm and clears the circulation of stray filaments. In vitro, gelsolin cleaves, nucleates and caps actin filaments, activities that are calcium-dependent. Both cellular and secreted forms share a sequence of 730 residues comprising six homologous modules termed G1-G6. A disulphide bond is formed in secreted G2, whereas in the cytoplasm it remains reduced. A point mutation in G2 causes an amyloidosis with neurological, ophthalmological and dermatological symptoms. This mutation does not affect the cytoplasmic form, while the secreted form is proteolysed. As a first step towards understanding how gelsolin folds and functions in different cellular compartments, we have characterized at equilibrium the urea-induced unfolding of G1 and G2, with or without calcium and/or disulphide bond. G1 and G2 both exhibit two-state unfolding behaviour and are stabilized by calcium. The disulphide bond also contributes to the stability of G2. In the absence of Ca(2+) and disulphide bond, G2 adopts a non-native conformation, suggesting that folding of G2 in the cytoplasm relies on the presence of surrounding modules or other molecular partners." @default.
- W2024862945 created "2016-06-24" @default.
- W2024862945 creator A5006001708 @default.
- W2024862945 creator A5014172613 @default.
- W2024862945 creator A5017178610 @default.
- W2024862945 creator A5038404795 @default.
- W2024862945 date "2000-09-08" @default.
- W2024862945 modified "2023-09-25" @default.
- W2024862945 title "Calcium-dependent conformational stability of modules 1 and 2 of human gelsolin" @default.
- W2024862945 cites W1531065454 @default.
- W2024862945 cites W1547929361 @default.
- W2024862945 cites W1553563097 @default.
- W2024862945 cites W1963698610 @default.
- W2024862945 cites W1965233966 @default.
- W2024862945 cites W1965310734 @default.
- W2024862945 cites W1970326408 @default.
- W2024862945 cites W1972002215 @default.
- W2024862945 cites W1976271455 @default.
- W2024862945 cites W1982044039 @default.
- W2024862945 cites W1982252808 @default.
- W2024862945 cites W1985290851 @default.
- W2024862945 cites W1994849711 @default.
- W2024862945 cites W2010654004 @default.
- W2024862945 cites W2010744273 @default.
- W2024862945 cites W2025026970 @default.
- W2024862945 cites W2028885172 @default.
- W2024862945 cites W2033056242 @default.
- W2024862945 cites W2036178039 @default.
- W2024862945 cites W2036931150 @default.
- W2024862945 cites W2056906682 @default.
- W2024862945 cites W2060394824 @default.
- W2024862945 cites W2068565403 @default.
- W2024862945 cites W2069521331 @default.
- W2024862945 cites W2070665737 @default.
- W2024862945 cites W2077462876 @default.
- W2024862945 cites W2078950445 @default.
- W2024862945 cites W2088570232 @default.
- W2024862945 cites W2095228340 @default.
- W2024862945 cites W2104017463 @default.
- W2024862945 cites W2116076986 @default.
- W2024862945 cites W2116269882 @default.
- W2024862945 cites W2156700030 @default.
- W2024862945 cites W2165111193 @default.
- W2024862945 cites W2165288717 @default.
- W2024862945 cites W2165721689 @default.
- W2024862945 doi "https://doi.org/10.1042/bj3500873" @default.
- W2024862945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1221322" @default.
- W2024862945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10970804" @default.
- W2024862945 hasPublicationYear "2000" @default.
- W2024862945 type Work @default.
- W2024862945 sameAs 2024862945 @default.
- W2024862945 citedByCount "21" @default.
- W2024862945 countsByYear W20248629452012 @default.
- W2024862945 countsByYear W20248629452014 @default.
- W2024862945 countsByYear W20248629452015 @default.
- W2024862945 countsByYear W20248629452018 @default.
- W2024862945 countsByYear W20248629452019 @default.
- W2024862945 countsByYear W20248629452021 @default.
- W2024862945 crossrefType "journal-article" @default.
- W2024862945 hasAuthorship W2024862945A5006001708 @default.
- W2024862945 hasAuthorship W2024862945A5014172613 @default.
- W2024862945 hasAuthorship W2024862945A5017178610 @default.
- W2024862945 hasAuthorship W2024862945A5038404795 @default.
- W2024862945 hasBestOaLocation W20248629452 @default.
- W2024862945 hasConcept C119599485 @default.
- W2024862945 hasConcept C12554922 @default.
- W2024862945 hasConcept C125705527 @default.
- W2024862945 hasConcept C127413603 @default.
- W2024862945 hasConcept C142669718 @default.
- W2024862945 hasConcept C1491633281 @default.
- W2024862945 hasConcept C178790620 @default.
- W2024862945 hasConcept C181199279 @default.
- W2024862945 hasConcept C185592680 @default.
- W2024862945 hasConcept C190062978 @default.
- W2024862945 hasConcept C2776545253 @default.
- W2024862945 hasConcept C519063684 @default.
- W2024862945 hasConcept C55493867 @default.
- W2024862945 hasConcept C80722340 @default.
- W2024862945 hasConcept C86803240 @default.
- W2024862945 hasConcept C95444343 @default.
- W2024862945 hasConcept C98539663 @default.
- W2024862945 hasConceptScore W2024862945C119599485 @default.
- W2024862945 hasConceptScore W2024862945C12554922 @default.
- W2024862945 hasConceptScore W2024862945C125705527 @default.
- W2024862945 hasConceptScore W2024862945C127413603 @default.
- W2024862945 hasConceptScore W2024862945C142669718 @default.
- W2024862945 hasConceptScore W2024862945C1491633281 @default.
- W2024862945 hasConceptScore W2024862945C178790620 @default.
- W2024862945 hasConceptScore W2024862945C181199279 @default.
- W2024862945 hasConceptScore W2024862945C185592680 @default.
- W2024862945 hasConceptScore W2024862945C190062978 @default.
- W2024862945 hasConceptScore W2024862945C2776545253 @default.
- W2024862945 hasConceptScore W2024862945C519063684 @default.
- W2024862945 hasConceptScore W2024862945C55493867 @default.
- W2024862945 hasConceptScore W2024862945C80722340 @default.
- W2024862945 hasConceptScore W2024862945C86803240 @default.
- W2024862945 hasConceptScore W2024862945C95444343 @default.
- W2024862945 hasConceptScore W2024862945C98539663 @default.