Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024864279> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2024864279 abstract "There are many reasons for people to miss work; one of the leading contributors is low back pain (LBP), which is believed to affect 80% of the population at some point during their lifetime. Suffering from back pain is the chief complaint of 5% of people who visit the doctor in the US [1]. The total medical cost related to low back pain in the US exceeds 100 billion dollars every year [2]. The cause of LBP is still unclear. However, recent studies revealed that intervertebral disc (IVD) degeneration is closely related to LBP [3]. IVD transfers loads and allows the spine to move through torsion, bending or compression [4–6]. There are two main anatomic regions in IVD: nucleus pulposus (NP) and annulus fibrosis (AF). The loss of notochordal cells in the NP region has been associated with the initiation of disc degeneration [7]. Our recent studies demonstrated that the adenosine triphosphate (ATP) production of notochordal NP cells was much higher than that of the AF cells while mechanical loading promoted ATP release from IVD cells [8]. Extracellular ATP (eATP) is a powerful signaling molecule that can mediate a wide variety of biological responses, such as cell metabolism, survival, and growth by binding to the purinergic receptors: G protein coupled receptor (P2Y) or ligand-gated ionotropic receptor (P2X) [9]. In addition, eATP is often rapidly hydrolyzed by several families of ectonucleotidases [10–12]. The by-products of eATP hydrolysis include inorganic pyrophosphate (PPi) and phosphate (Pi) which are closely related to mineral crystal formation and tissue calcification [12–15]. PPi and Pi released from eATP hydrolysis may contribute to endplate calcification which has been associated with disc degeneration. However, eATP accumulation in the IVD has not been studied yet. Therefore, the objective of this study was to investigate the accumulative level of eATP in the NP region of porcine IVD using a novel optical ATP sensor." @default.
- W2024864279 created "2016-06-24" @default.
- W2024864279 creator A5007803202 @default.
- W2024864279 creator A5026453606 @default.
- W2024864279 creator A5036713983 @default.
- W2024864279 creator A5086679102 @default.
- W2024864279 date "2012-06-20" @default.
- W2024864279 modified "2023-09-27" @default.
- W2024864279 title "Accumulation of Extracellular ATP in Porcine Nucleus Pulposus" @default.
- W2024864279 doi "https://doi.org/10.1115/sbc2012-80671" @default.
- W2024864279 hasPublicationYear "2012" @default.
- W2024864279 type Work @default.
- W2024864279 sameAs 2024864279 @default.
- W2024864279 citedByCount "0" @default.
- W2024864279 crossrefType "proceedings-article" @default.
- W2024864279 hasAuthorship W2024864279A5007803202 @default.
- W2024864279 hasAuthorship W2024864279A5026453606 @default.
- W2024864279 hasAuthorship W2024864279A5036713983 @default.
- W2024864279 hasAuthorship W2024864279A5086679102 @default.
- W2024864279 hasConcept C105702510 @default.
- W2024864279 hasConcept C126322002 @default.
- W2024864279 hasConcept C141315368 @default.
- W2024864279 hasConcept C170493617 @default.
- W2024864279 hasConcept C172590197 @default.
- W2024864279 hasConcept C181199279 @default.
- W2024864279 hasConcept C185592680 @default.
- W2024864279 hasConcept C23265538 @default.
- W2024864279 hasConcept C2777755357 @default.
- W2024864279 hasConcept C2778938600 @default.
- W2024864279 hasConcept C2779564974 @default.
- W2024864279 hasConcept C28406088 @default.
- W2024864279 hasConcept C2908647359 @default.
- W2024864279 hasConcept C55493867 @default.
- W2024864279 hasConcept C57306754 @default.
- W2024864279 hasConcept C67907053 @default.
- W2024864279 hasConcept C71924100 @default.
- W2024864279 hasConcept C86803240 @default.
- W2024864279 hasConcept C95444343 @default.
- W2024864279 hasConcept C99454951 @default.
- W2024864279 hasConceptScore W2024864279C105702510 @default.
- W2024864279 hasConceptScore W2024864279C126322002 @default.
- W2024864279 hasConceptScore W2024864279C141315368 @default.
- W2024864279 hasConceptScore W2024864279C170493617 @default.
- W2024864279 hasConceptScore W2024864279C172590197 @default.
- W2024864279 hasConceptScore W2024864279C181199279 @default.
- W2024864279 hasConceptScore W2024864279C185592680 @default.
- W2024864279 hasConceptScore W2024864279C23265538 @default.
- W2024864279 hasConceptScore W2024864279C2777755357 @default.
- W2024864279 hasConceptScore W2024864279C2778938600 @default.
- W2024864279 hasConceptScore W2024864279C2779564974 @default.
- W2024864279 hasConceptScore W2024864279C28406088 @default.
- W2024864279 hasConceptScore W2024864279C2908647359 @default.
- W2024864279 hasConceptScore W2024864279C55493867 @default.
- W2024864279 hasConceptScore W2024864279C57306754 @default.
- W2024864279 hasConceptScore W2024864279C67907053 @default.
- W2024864279 hasConceptScore W2024864279C71924100 @default.
- W2024864279 hasConceptScore W2024864279C86803240 @default.
- W2024864279 hasConceptScore W2024864279C95444343 @default.
- W2024864279 hasConceptScore W2024864279C99454951 @default.
- W2024864279 hasLocation W20248642791 @default.
- W2024864279 hasOpenAccess W2024864279 @default.
- W2024864279 hasPrimaryLocation W20248642791 @default.
- W2024864279 hasRelatedWork W1929587128 @default.
- W2024864279 hasRelatedWork W1998715799 @default.
- W2024864279 hasRelatedWork W2011724488 @default.
- W2024864279 hasRelatedWork W2016983742 @default.
- W2024864279 hasRelatedWork W2018587908 @default.
- W2024864279 hasRelatedWork W2021513442 @default.
- W2024864279 hasRelatedWork W2054435436 @default.
- W2024864279 hasRelatedWork W2070683511 @default.
- W2024864279 hasRelatedWork W2118561198 @default.
- W2024864279 hasRelatedWork W2126876140 @default.
- W2024864279 hasRelatedWork W2138305086 @default.
- W2024864279 hasRelatedWork W2140812406 @default.
- W2024864279 hasRelatedWork W2142842782 @default.
- W2024864279 hasRelatedWork W2788351755 @default.
- W2024864279 hasRelatedWork W2885639289 @default.
- W2024864279 hasRelatedWork W2922292398 @default.
- W2024864279 hasRelatedWork W3018403710 @default.
- W2024864279 hasRelatedWork W3186836772 @default.
- W2024864279 hasRelatedWork W3210513320 @default.
- W2024864279 hasRelatedWork W2468196719 @default.
- W2024864279 isParatext "false" @default.
- W2024864279 isRetracted "false" @default.
- W2024864279 magId "2024864279" @default.
- W2024864279 workType "article" @default.