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• W2024866056 endingPage "e2696" @default.
• W2024866056 startingPage "e2696" @default.
• W2024866056 abstract "Scleroderma is a clinically heterogeneous disease with a complex phenotype. The disease is characterized by vascular dysfunction, tissue fibrosis, internal organ dysfunction, and immune dysfunction resulting in autoantibody production.We analyzed the genome-wide patterns of gene expression with DNA microarrays in skin biopsies from distinct scleroderma subsets including 17 patients with systemic sclerosis (SSc) with diffuse scleroderma (dSSc), 7 patients with SSc with limited scleroderma (lSSc), 3 patients with morphea, and 6 healthy controls. 61 skin biopsies were analyzed in a total of 75 microarray hybridizations. Analysis by hierarchical clustering demonstrates nearly identical patterns of gene expression in 17 out of 22 of the forearm and back skin pairs of SSc patients. Using this property of the gene expression, we selected a set of 'intrinsic' genes and analyzed the inherent data-driven groupings. Distinct patterns of gene expression separate patients with dSSc from those with lSSc and both are easily distinguished from normal controls. Our data show three distinct patient groups among the patients with dSSc and two groups among patients with lSSc. Each group can be distinguished by unique gene expression signatures indicative of proliferating cells, immune infiltrates and a fibrotic program. The intrinsic groups are statistically significant (p<0.001) and each has been mapped to clinical covariates of modified Rodnan skin score, interstitial lung disease, gastrointestinal involvement, digital ulcers, Raynaud's phenomenon and disease duration. We report a 177-gene signature that is associated with severity of skin disease in dSSc.Genome-wide gene expression profiling of skin biopsies demonstrates that the heterogeneity in scleroderma can be measured quantitatively with DNA microarrays. The diversity in gene expression demonstrates multiple distinct gene expression programs in the skin of patients with scleroderma." @default.
• W2024866056 created "2016-06-24" @default.
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• W2024866056 date "2008-07-16" @default.
• W2024866056 modified "2023-10-17" @default.
• W2024866056 title "Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin" @default.
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• W2024866056 cites W1823060599 @default.
• W2024866056 cites W1913068299 @default.
• W2024866056 cites W1974753304 @default.
• W2024866056 cites W1977859620 @default.
• W2024866056 cites W1982730007 @default.
• W2024866056 cites W1988078905 @default.
• W2024866056 cites W1989076816 @default.
• W2024866056 cites W1989091670 @default.
• W2024866056 cites W1989109175 @default.
• W2024866056 cites W1992449855 @default.
• W2024866056 cites W2001134797 @default.
• W2024866056 cites W2003599597 @default.
• W2024866056 cites W2007187686 @default.
• W2024866056 cites W2014765246 @default.
• W2024866056 cites W2018173663 @default.
• W2024866056 cites W2027613172 @default.
• W2024866056 cites W2028417672 @default.
• W2024866056 cites W2034516005 @default.
• W2024866056 cites W2035377569 @default.
• W2024866056 cites W2042248645 @default.
• W2024866056 cites W2049784193 @default.
• W2024866056 cites W2055575746 @default.
• W2024866056 cites W2058661633 @default.
• W2024866056 cites W2060182310 @default.
• W2024866056 cites W2064407013 @default.
• W2024866056 cites W2070987468 @default.
• W2024866056 cites W2072898497 @default.
• W2024866056 cites W2077533512 @default.
• W2024866056 cites W2079965786 @default.
• W2024866056 cites W2085467313 @default.
• W2024866056 cites W2086326784 @default.
• W2024866056 cites W2092280881 @default.
• W2024866056 cites W2094334874 @default.
• W2024866056 cites W2095330800 @default.
• W2024866056 cites W2097255042 @default.
• W2024866056 cites W2100682112 @default.
• W2024866056 cites W2105712639 @default.
• W2024866056 cites W2107277218 @default.
• W2024866056 cites W2115637648 @default.
• W2024866056 cites W2116830437 @default.
• W2024866056 cites W2123054757 @default.
• W2024866056 cites W2127053639 @default.
• W2024866056 cites W2131994307 @default.
• W2024866056 cites W2134364025 @default.
• W2024866056 cites W2137071299 @default.
• W2024866056 cites W2138211373 @default.
• W2024866056 cites W2141059777 @default.
• W2024866056 cites W2142718675 @default.
• W2024866056 cites W2147246240 @default.
• W2024866056 cites W2148943468 @default.
• W2024866056 cites W2150926065 @default.
• W2024866056 cites W2152773186 @default.
• W2024866056 cites W2152887115 @default.
• W2024866056 cites W2152996717 @default.
• W2024866056 cites W2155173012 @default.
• W2024866056 cites W2155460347 @default.
• W2024866056 cites W2155612034 @default.
• W2024866056 cites W2155913937 @default.
• W2024866056 cites W2157840751 @default.
• W2024866056 cites W2159686118 @default.
• W2024866056 cites W2165096626 @default.
• W2024866056 cites W2165270659 @default.
• W2024866056 cites W2167936032 @default.
• W2024866056 cites W2168198817 @default.
• W2024866056 cites W2181131337 @default.
• W2024866056 cites W2214642837 @default.
• W2024866056 cites W4294107304 @default.
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• W2024866056 doi "https://doi.org/10.1371/journal.pone.0002696" @default.
• W2024866056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2481301" @default.
• W2024866056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18648520" @default.
• W2024866056 hasPublicationYear "2008" @default.
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