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- W2024870129 abstract "Summary In France, meningococcal meningitis and meningococcemia occur at an incidence of 0.8 per 100.000. As about 10 % of cases are fatal, these two diseases pose a serious threat to public health. Doctors are obliged to declare cases to the French Direction Generale de la Sante (DGS). Cases (2817) declared at the DGS from 1985 to 1991 reveal that the death rate from meningitis and meningococcemia is elevated in young children and young adults (with a predominance of serogroup C in the latter) when meningitis is associated with meningococcemia or extensive purpura fulminans, and when certain serogroups are present (A and C). For such cases, the use of rifampicin appears to have become normal practice since distribution of a circular by the French Ministry of Health (Department of Health) in February 1990; however, it is necessary to improve vaccinal practice against meningococci A and C. In addition, analysis of the meningococcal strains (1569) addressed to the Centre National de Reference des Meningocoques et Neisseria apparentees (CNRM) from 1989 to 1992 for complementary examination (serotypes, subtypes) revealed a stronger incidence of serogroup B in extremely heterogeneous antigenic formulae of which the strains B:15:P1.7,16 are encountered most frequently. Also noted, were progressions of serogroup C (42 % of isolates in 1992; major antigenic formula, C:2a:P1.1,2) and serogroup Y (2–3 %). The clinical evolution of cases associated with 556 strains examined at both the DGS and the CNRM revealed elevated death rates associated with serotype 2a and subtype P1.1,2 and a low death rate associated with serotype 4. Improved channels for declaration of cases (more exhaustive, more rapid) and research on other antigenic markers ought to enhance prevention of secondary cases and allow better monitoring of epidemic and/or virulent strains." @default.
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- W2024870129 date "1995-04-01" @default.
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- W2024870129 title "Meningococcal meningitis and meningococcemia : epidemiological study, France (1985–1991)" @default.
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- W2024870129 doi "https://doi.org/10.1016/s0399-077x(05)81031-5" @default.
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