Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024872019> ?p ?o ?g. }
- W2024872019 endingPage "534" @default.
- W2024872019 startingPage "525" @default.
- W2024872019 abstract "Immunoselected CD34+ peripheral blood progenitor cell (PBPC) transplantation is now frequently used to support autologous hematopoiesis after myeloablative therapy, its feasability having been proved by several groups. However, we and others observed delayed platelet recovery. We hypothesized that immunoselection processing might induce selective loss of megakaryocyte progenitors, or a decrease in their proliferation. We used a colony-forming units megakaryocyte (CFU-Mk) assay to evaluate these consequences and predict platelet recovery in patients. In CD34+ PBPCs from 10 children with solid tumors, we observed no selective loss in CFU-Mk numbers during immunoselection processing and no impairment of clonogenicity. The CFU-Mk yield (59.2 plusmn; 11.3%) was at least similar to the CD34+ yield (44.2 ± 3.8%). We assessed the predictive value of CFU-Mk numbers infused for recovery of platelet lineage. We found an inverse correlation between the time taken to reach a platelet count greater than 50 X 109/L and only the CFU-Mk dose (r = -0.71; p = 0.022) among the different type of progenitors, including colony-forming units granulocytemacrophage (CFU-GM), burst-forming units erythrocyte (BFU-E) and colony-forming units-mixed (CFU-Mix). These findings suggest that CFU-Mk number could be used as sole predictive functional parameter for platelet reconstitution in children after immunoselection of CD34+ cells, in particular for low CD34+ cell dose, and thus as an indicator for initial quality of hematopoietic cells before in vitro expansion." @default.
- W2024872019 created "2016-06-24" @default.
- W2024872019 creator A5011288919 @default.
- W2024872019 creator A5011684500 @default.
- W2024872019 creator A5020067321 @default.
- W2024872019 creator A5023552802 @default.
- W2024872019 creator A5045981135 @default.
- W2024872019 creator A5049969589 @default.
- W2024872019 creator A5058383500 @default.
- W2024872019 creator A5061164405 @default.
- W2024872019 creator A5067261312 @default.
- W2024872019 creator A5068506732 @default.
- W2024872019 creator A5072585912 @default.
- W2024872019 creator A5074305679 @default.
- W2024872019 creator A5087192702 @default.
- W2024872019 date "2000-08-01" @default.
- W2024872019 modified "2023-09-23" @default.
- W2024872019 title "CFU-Mk Content of Immunoselected CD34+Peripheral Blood Progenitor Cells, Evaluated with an Adapted Serum-Free Methylcellulose Assay, Is Predictive of Platelet Lineage Reconstitution in Children with Solid Tumors" @default.
- W2024872019 cites W120762819 @default.
- W2024872019 cites W1502960213 @default.
- W2024872019 cites W160332237 @default.
- W2024872019 cites W1852147417 @default.
- W2024872019 cites W1901008785 @default.
- W2024872019 cites W190906149 @default.
- W2024872019 cites W1970736113 @default.
- W2024872019 cites W1972394840 @default.
- W2024872019 cites W1979014936 @default.
- W2024872019 cites W1981062788 @default.
- W2024872019 cites W1981542577 @default.
- W2024872019 cites W1987023303 @default.
- W2024872019 cites W1988068150 @default.
- W2024872019 cites W1990967532 @default.
- W2024872019 cites W1998608957 @default.
- W2024872019 cites W2004282492 @default.
- W2024872019 cites W2019928354 @default.
- W2024872019 cites W2020545711 @default.
- W2024872019 cites W2033107662 @default.
- W2024872019 cites W2035343600 @default.
- W2024872019 cites W2050724077 @default.
- W2024872019 cites W2052107982 @default.
- W2024872019 cites W2059052465 @default.
- W2024872019 cites W2060162536 @default.
- W2024872019 cites W2064114801 @default.
- W2024872019 cites W2068409711 @default.
- W2024872019 cites W2073101215 @default.
- W2024872019 cites W2074304946 @default.
- W2024872019 cites W2081443875 @default.
- W2024872019 cites W2081670151 @default.
- W2024872019 cites W2118643026 @default.
- W2024872019 cites W2125887123 @default.
- W2024872019 cites W2137392293 @default.
- W2024872019 cites W2179601534 @default.
- W2024872019 cites W2252485852 @default.
- W2024872019 cites W2300654763 @default.
- W2024872019 cites W2309502478 @default.
- W2024872019 cites W2313354898 @default.
- W2024872019 cites W232095477 @default.
- W2024872019 cites W2342210190 @default.
- W2024872019 cites W4251845825 @default.
- W2024872019 doi "https://doi.org/10.1089/152581600419206" @default.
- W2024872019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10982252" @default.
- W2024872019 hasPublicationYear "2000" @default.
- W2024872019 type Work @default.
- W2024872019 sameAs 2024872019 @default.
- W2024872019 citedByCount "13" @default.
- W2024872019 countsByYear W20248720192012 @default.
- W2024872019 countsByYear W20248720192013 @default.
- W2024872019 countsByYear W20248720192014 @default.
- W2024872019 crossrefType "journal-article" @default.
- W2024872019 hasAuthorship W2024872019A5011288919 @default.
- W2024872019 hasAuthorship W2024872019A5011684500 @default.
- W2024872019 hasAuthorship W2024872019A5020067321 @default.
- W2024872019 hasAuthorship W2024872019A5023552802 @default.
- W2024872019 hasAuthorship W2024872019A5045981135 @default.
- W2024872019 hasAuthorship W2024872019A5049969589 @default.
- W2024872019 hasAuthorship W2024872019A5058383500 @default.
- W2024872019 hasAuthorship W2024872019A5061164405 @default.
- W2024872019 hasAuthorship W2024872019A5067261312 @default.
- W2024872019 hasAuthorship W2024872019A5068506732 @default.
- W2024872019 hasAuthorship W2024872019A5072585912 @default.
- W2024872019 hasAuthorship W2024872019A5074305679 @default.
- W2024872019 hasAuthorship W2024872019A5087192702 @default.
- W2024872019 hasConcept C10205521 @default.
- W2024872019 hasConcept C109159458 @default.
- W2024872019 hasConcept C126322002 @default.
- W2024872019 hasConcept C153911025 @default.
- W2024872019 hasConcept C16685009 @default.
- W2024872019 hasConcept C201750760 @default.
- W2024872019 hasConcept C202751555 @default.
- W2024872019 hasConcept C203014093 @default.
- W2024872019 hasConcept C2777279920 @default.
- W2024872019 hasConcept C2779705218 @default.
- W2024872019 hasConcept C28328180 @default.
- W2024872019 hasConcept C2911091166 @default.
- W2024872019 hasConcept C55493867 @default.
- W2024872019 hasConcept C71924100 @default.
- W2024872019 hasConcept C86803240 @default.
- W2024872019 hasConcept C89560881 @default.