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- W2024874473 abstract "The metabolism of [ethyl-14C]phenacetin in the rat and rabbit respiratory tract was studied. As shown by whole-body autoradiography, a selective binding of radioactivity occurred in the mucosa of the rat respiratory tract 5 min after an i.v. injection of [ethyl-14C]phenacetin. Microautoradiography showed that tissue-bound radioactivity was present in the epithelium of the nasal and tracheo-bronchial mucosa and in subepithelial glands in the olfactory mucosa. In vitro experiments showed that the mucosa of the rat and rabbit respiratory tract had a marked ability to metabolize [ethyl-14C]phenacetin, as determined by 14CO2 formation and binding of radioactivity to the mucosa. The results indicate that in situ metabolism of phenacetin in the nasal mucosa may play a role in the pathogenesis of phenacetin-induced tumours in the nasal region of rats." @default.
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- W2024874473 date "1984-07-01" @default.
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- W2024874473 title "Metabolism of a nasal carcinogen, phenacetin, in the mucosa of the upper respiratory tract" @default.
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- W2024874473 doi "https://doi.org/10.1016/0009-2797(84)90099-1" @default.
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