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- W2024880091 abstract "Quinolinic acid (QA) causes excitotoxicity by stimulating N-methyl-D-aspartate (NMDA) receptors via calcium overload leading to neurodegeneration. Neuroprotective potential of peroxisome proliferator activated receptor-γ (PPARγ) agonists and histone deacetylase (HDAC) inhibitors have been well documented in experimental models of neurodegenerative disorders; however, their exact mechanisms are not clear. Oxidative damage, neuro-inflammation, apoptosis, protein aggregation and signalling of neurotrophic factors are some of the common cellular pathways involved in QA mediated neurotoxicity.Therefore, present study has been designed to explore possible neuroprotective mechanism of valproic acid and its interaction with rosiglitazone against QA induced HD like symptoms in rats. QA (200 nmol) was administered intrastriatally and bilaterally to the rats. Animals were treated with rosiglitazone, valproate and their combination for 21 days following QA administration. Several behavioural and biochemical parameters were accessed in weekly interval for 21 days. Single bilateral intrastriatal QA (200 nmol/2 μl saline) administration significantly caused motor incordination, memory impairment, oxidative damage, mitochondrial dysfunction (Complex I, II, II and IV), cellular alterations [tumour necrosis factor-alpha (TNF-α), caspase-3, brain derived neurotrophic factor (BDNF), acetylcholinesterase) and striatal neurodegeneration as compared to sham group. Treatment with rosiglitazone (5, 10 mg/kg) and valproic acid (100, 200 mg/kg) for 21 days significantly attenuated these behavioral, biochemical and cellular alterations as compared to control (QA 200 nmol) group. However, valproic acid (100 mg/kg) treatment in combination with rosiglitazone (5 mg/kg) for 21 days synergised their neuroprotective effect which was significant as compared to their effects per se in QA treated animals." @default.
- W2024880091 created "2016-06-24" @default.
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- W2024880091 date "2014-07-01" @default.
- W2024880091 modified "2023-09-28" @default.
- W2024880091 title "P2-138: ROSIGLITAZONE SYNERGISES THE NEUROPROTECTIVE EFFECTS OF VALPROIC ACID AGAINST QUINOLINIC ACID INDUCED NEUROTOXICITY AND ASSOCIATED COGNITIVE IMPAIRMENT IN RATS: TARGETING PPARγ AND HDAC PATHWAYS" @default.
- W2024880091 doi "https://doi.org/10.1016/j.jalz.2014.05.813" @default.
- W2024880091 hasPublicationYear "2014" @default.
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