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- W2024880762 abstract "Summary: The rate of occurrence of audiogenic seizures and seizures induced by the benzodiazepine receptor inverse agonist methyl-β-carboline-3-carboxylate (β-CCM) were analyzed in several recombinant congenic strains of mice bred from B10.D2 and DBA/2J. Although both types of seizures have similar behavioral patterns and might involve GABAergic mechanisms, no correlation was observed between the occurrence of the two types of seizures across the strains, suggesting that these two types of seizures depend on different genetic mechanisms. La frecuencia de los ataques audiogénicos y los ataques inducidos por los agonistas inversos del receptor de la benzodiacepina, el metil-β-carbolin-3-carboxilato (β-CCM), se han analizado en varias líneas de ratones recombinantes congénicos obtenidos de las especies B 10.D2 y DBA/2J. A pesar de que ambos tipos de ataques tienen patrones de comportamiento semejantes, que pueden incluir mecanismos gabaérgicos, no se observó ninguna correlación entre la aparición de estos dos tipos de ataques en las diferentes líneas de ratones, lo que sugiere que estos dos tipos de ataques dependen de mecanismos genéticos diferentes. Die Häufigkeit von audiogenen Anfällen und von Anfällen, die durch den Benzodiazepinrezeptor inversen Agonisten Methylbeta-Carbolin-3-Carboxylat (B-CCM) erzeugt wurden, wurde bei verschiedenen rekombinanten Mäusestämmen (B 10.D2 und DBA/2J) untersucht. Obwohl beide Anfallstypen ähnliche Verhaltensmuster zeigten und möglicherweise Gaba-erge Mechanismen involvieren, wurde keine Korrelation zwischen beiden Anfallstypen bei den Stämmen beobachtet, was nahelegt, daβ die beieden Anfallstypen von verschiedenen genetischen Mechanismen abhängen." @default.
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- W2024880762 title "Analysis of B 10.D2 Recombinant Congenic Mouse Strains Shows That Audiogenic and beta-CCM-Induced Seizures Depend on Different Genetic Mechanisms" @default.
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- W2024880762 doi "https://doi.org/10.1111/j.1528-1157.1992.tb02276.x" @default.
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