Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024881404> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2024881404 endingPage "320" @default.
- W2024881404 startingPage "313" @default.
- W2024881404 abstract "In this study, we present significant changes occurring in serum drug concentrations while using blood collection tubes that contain a barrier gel. This report also contains results with antidepressant drugs, which have not been studied before with human samples. The drug concentrations were measured either with high performance liquid chromatography (HPLC) or fluorescence polarization immunoassay (FPIA). The results show that gel tubes are suitable for blood collection for antiepileptic, antibiotic, asthma and cardioactive drug measurements, since only slight adsorption was seen (0-5%). However, the studied tubes are not suitable for blood collection of antidepressants nor benzodiazepines, because the adsorption can be 5-30%. The adsorption was even higher (up to 40%) when samples were stored for 24 h after centrifugation in gel tubes. When the centrifugation step was performed after storage the effect of the barrier gel was lower (only 0-13%). Antidepressant drug measurements performed from patient specimens collected in the studied gel tubes and stored for 3 h showed <10% adsorption of the studied drugs. After 24 h storage time, concentrations of all analysed drugs decreased even more: adsorbed amount of drugs were about 5-20%. The studied gel tubes are proposed to be satisfactory for blood collection for antidepressant drug measurements if separation step is performed within 3 h after blood clotting. With the spiked samples the adsorption to barrier gel was higher, so it seems that adsorption is faster when drugs are not highly bound to serum proteins." @default.
- W2024881404 created "2016-06-24" @default.
- W2024881404 creator A5049808528 @default.
- W2024881404 creator A5050243597 @default.
- W2024881404 creator A5072080848 @default.
- W2024881404 date "2000-04-30" @default.
- W2024881404 modified "2023-09-24" @default.
- W2024881404 title "Suitability of Collection Tubes with Separator Gels for Collecting and Storing Blood Samples for Therapeutic Drug Monitoring (TDM)" @default.
- W2024881404 cites W1839297875 @default.
- W2024881404 cites W1879320329 @default.
- W2024881404 cites W1941741688 @default.
- W2024881404 cites W1963572878 @default.
- W2024881404 cites W2016286238 @default.
- W2024881404 cites W2031802598 @default.
- W2024881404 cites W2049966425 @default.
- W2024881404 cites W2060913752 @default.
- W2024881404 cites W2063706329 @default.
- W2024881404 cites W2150696535 @default.
- W2024881404 cites W2319305077 @default.
- W2024881404 cites W2324479730 @default.
- W2024881404 cites W2999104807 @default.
- W2024881404 cites W4298280280 @default.
- W2024881404 cites W4299853637 @default.
- W2024881404 doi "https://doi.org/10.1515/cclm.2000.045" @default.
- W2024881404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10928651" @default.
- W2024881404 hasPublicationYear "2000" @default.
- W2024881404 type Work @default.
- W2024881404 sameAs 2024881404 @default.
- W2024881404 citedByCount "46" @default.
- W2024881404 countsByYear W20248814042012 @default.
- W2024881404 countsByYear W20248814042013 @default.
- W2024881404 countsByYear W20248814042014 @default.
- W2024881404 countsByYear W20248814042015 @default.
- W2024881404 countsByYear W20248814042016 @default.
- W2024881404 countsByYear W20248814042017 @default.
- W2024881404 countsByYear W20248814042018 @default.
- W2024881404 countsByYear W20248814042019 @default.
- W2024881404 countsByYear W20248814042020 @default.
- W2024881404 countsByYear W20248814042021 @default.
- W2024881404 countsByYear W20248814042022 @default.
- W2024881404 countsByYear W20248814042023 @default.
- W2024881404 crossrefType "journal-article" @default.
- W2024881404 hasAuthorship W2024881404A5049808528 @default.
- W2024881404 hasAuthorship W2024881404A5050243597 @default.
- W2024881404 hasAuthorship W2024881404A5072080848 @default.
- W2024881404 hasConcept C150394285 @default.
- W2024881404 hasConcept C178790620 @default.
- W2024881404 hasConcept C185592680 @default.
- W2024881404 hasConcept C194828623 @default.
- W2024881404 hasConcept C2780035454 @default.
- W2024881404 hasConcept C2994091943 @default.
- W2024881404 hasConcept C43617362 @default.
- W2024881404 hasConcept C71924100 @default.
- W2024881404 hasConcept C7623868 @default.
- W2024881404 hasConcept C98274493 @default.
- W2024881404 hasConceptScore W2024881404C150394285 @default.
- W2024881404 hasConceptScore W2024881404C178790620 @default.
- W2024881404 hasConceptScore W2024881404C185592680 @default.
- W2024881404 hasConceptScore W2024881404C194828623 @default.
- W2024881404 hasConceptScore W2024881404C2780035454 @default.
- W2024881404 hasConceptScore W2024881404C2994091943 @default.
- W2024881404 hasConceptScore W2024881404C43617362 @default.
- W2024881404 hasConceptScore W2024881404C71924100 @default.
- W2024881404 hasConceptScore W2024881404C7623868 @default.
- W2024881404 hasConceptScore W2024881404C98274493 @default.
- W2024881404 hasIssue "4" @default.
- W2024881404 hasLocation W20248814041 @default.
- W2024881404 hasLocation W20248814042 @default.
- W2024881404 hasOpenAccess W2024881404 @default.
- W2024881404 hasPrimaryLocation W20248814041 @default.
- W2024881404 hasRelatedWork W1975215705 @default.
- W2024881404 hasRelatedWork W2006954969 @default.
- W2024881404 hasRelatedWork W2047747137 @default.
- W2024881404 hasRelatedWork W2084097635 @default.
- W2024881404 hasRelatedWork W2094635201 @default.
- W2024881404 hasRelatedWork W2356281379 @default.
- W2024881404 hasRelatedWork W2366801190 @default.
- W2024881404 hasRelatedWork W2370080600 @default.
- W2024881404 hasRelatedWork W2392582611 @default.
- W2024881404 hasRelatedWork W2469776427 @default.
- W2024881404 hasVolume "38" @default.
- W2024881404 isParatext "false" @default.
- W2024881404 isRetracted "false" @default.
- W2024881404 magId "2024881404" @default.
- W2024881404 workType "article" @default.