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• W2024882507 startingPage "497" @default.
• W2024882507 abstract "In eukaryotic chemotaxis, the mechanisms connecting external signals to the motile apparatus remain unclear. The role of the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP3) has been particularly controversial. PIP3 has many cellular roles, notably in growth control and macropinocytosis as well as cell motility. Here we show that PIP3 is not only unnecessary for Dictyostelium discoideum to migrate toward folate, but actively inhibits chemotaxis. We find that macropinosomes, but not pseudopods, in growing cells are dependent on PIP3. PIP3 patches in these cells show no directional bias, and overall only PIP3-free pseudopods orient up-gradient. The pseudopod driver suppressor of cAR mutations (SCAR)/WASP and verprolin homologue (WAVE) is not recruited to the center of PIP3 patches, just the edges, where it causes macropinosome formation. Wild-type cells, unlike the widely used axenic mutants, show little macropinocytosis and few large PIP3 patches, but migrate more efficiently toward folate. Tellingly, folate chemotaxis in axenic cells is rescued by knocking out phosphatidylinositide 3-kinases (PI 3-kinases). Thus PIP3 promotes macropinocytosis and interferes with pseudopod orientation during chemotaxis of growing cells." @default.
• W2024882507 created "2016-06-24" @default.
• W2024882507 creator A5011491185 @default.
• W2024882507 creator A5021831908 @default.
• W2024882507 creator A5053963155 @default.
• W2024882507 creator A5054741862 @default.
• W2024882507 date "2014-02-17" @default.
• W2024882507 modified "2023-10-15" @default.
• W2024882507 title "PIP3-dependent macropinocytosis is incompatible with chemotaxis" @default.
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• W2024882507 doi "https://doi.org/10.1083/jcb.201309081" @default.
• W2024882507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3926956" @default.
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