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- W2024882852 abstract "It is known that the lac operon regulatory pathway is capable of showing bistable behavior. This is an important complex feature, arising from the nonlinearity of the involved mechanisms, which is essential to understand the dynamic behavior of this molecular regulatory system. To find which of the mechanisms involved in the regulation of the lac operon is the origin of bistability, we take a previously published model which accounts for the dynamics of mRNA, lactose, allolactose, permease and β-galactosidase involvement and simplify it by ignoring permease dynamics (assuming a constant permease concentration). To test the behavior of the reduced model, three existing sets of data on β-galactosidase levels as a function of time are simulated and we obtain a reasonable agreement between the data and the model predictions. The steady states of the reduced model were numerically and analytically analyzed and it was shown that it may indeed display bistability, depending on the extracellular lactose concentration and growth rate." @default.
- W2024882852 created "2016-06-24" @default.
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- W2024882852 date "2004-05-11" @default.
- W2024882852 modified "2023-09-26" @default.
- W2024882852 title "Dynamics and bistability in a reduced model of the<i>lac</i>operon" @default.
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- W2024882852 doi "https://doi.org/10.1063/1.1689451" @default.
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