FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024883161> ?p ?o ?g. }

• W2024883161 endingPage "30783" @default.
• W2024883161 startingPage "30778" @default.
• W2024883161 abstract "The activation of monocytes involves a stimulation of glycolysis, release of potent inflammatory mediators, and alterations in gene expression. All of these processes are known to be further increased under hypoxic conditions. The activated monocytes express inducible 6-phosphofructo-2-kinase (iPFK-2), which synthesizes fructose 2,6-bisphosphate, a stimulator of glycolysis. During ischemia, AMP-activated protein kinase (AMPK) activates the homologous heart 6-phosphofructo-2-kinase isoform by phosphorylating its Ser-466. Here, we studied the involvement of AMPK and iPFK-2 in the stimulation of glycolysis in activated monocytes under hypoxia. iPFK-2 was phosphorylated on the homologous serine (Ser-461) and activated by AMPK in vitro. The activation of human monocytes by lipopolysaccharide induced iPFK-2 expression and increased fructose 2,6-bisphosphate content and glycolysis. The incubation of activated monocytes with oligomycin, an inhibitor of oxidative phosphorylation, or under hypoxic conditions activated AMPK and further increased iPFK-2 activity, fructose 2,6-bisphosphate content, and glycolysis. In cultured human embryonic kidney 293 cells, the expression of a dominant-negative AMPK prevented both the activation and phosphorylation of co-transfected iPFK-2 by oligomycin. It is concluded that the stimulation of glycolysis by hypoxia in activated monocytes requires the phosphorylation and activation of iPFK-2 by AMPK." @default.
• W2024883161 created "2016-06-24" @default.
• W2024883161 creator A5039129582 @default.
• W2024883161 creator A5050253703 @default.
• W2024883161 creator A5058916083 @default.
• W2024883161 creator A5079037154 @default.
• W2024883161 date "2002-08-01" @default.
• W2024883161 modified "2023-09-30" @default.
• W2024883161 title "The Stimulation of Glycolysis by Hypoxia in Activated Monocytes Is Mediated by AMP-activated Protein Kinase and Inducible 6-Phosphofructo-2-kinase" @default.
• W2024883161 cites W1543440244 @default.
• W2024883161 cites W1565979608 @default.
• W2024883161 cites W1673084462 @default.
• W2024883161 cites W1676880150 @default.
• W2024883161 cites W1735368814 @default.
• W2024883161 cites W1745111908 @default.
• W2024883161 cites W1972682491 @default.
• W2024883161 cites W1972762474 @default.
• W2024883161 cites W1984371704 @default.
• W2024883161 cites W1989862997 @default.
• W2024883161 cites W1999509419 @default.
• W2024883161 cites W2000081372 @default.
• W2024883161 cites W2011241671 @default.
• W2024883161 cites W2015396179 @default.
• W2024883161 cites W2027072703 @default.
• W2024883161 cites W2028268047 @default.
• W2024883161 cites W2031458979 @default.
• W2024883161 cites W2038817100 @default.
• W2024883161 cites W2051502501 @default.
• W2024883161 cites W2053299934 @default.
• W2024883161 cites W2065699321 @default.
• W2024883161 cites W2067522487 @default.
• W2024883161 cites W2077230920 @default.
• W2024883161 cites W2079854321 @default.
• W2024883161 cites W2121105123 @default.
• W2024883161 cites W2129526202 @default.
• W2024883161 cites W2147594695 @default.
• W2024883161 cites W2157804459 @default.
• W2024883161 cites W2158631571 @default.
• W2024883161 cites W2170880090 @default.
• W2024883161 doi "https://doi.org/10.1074/jbc.m205213200" @default.
• W2024883161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12065600" @default.
• W2024883161 hasPublicationYear "2002" @default.
• W2024883161 type Work @default.
• W2024883161 sameAs 2024883161 @default.
• W2024883161 citedByCount "324" @default.
• W2024883161 countsByYear W20248831612012 @default.
• W2024883161 countsByYear W20248831612013 @default.
• W2024883161 countsByYear W20248831612014 @default.
• W2024883161 countsByYear W20248831612015 @default.
• W2024883161 countsByYear W20248831612016 @default.
• W2024883161 countsByYear W20248831612017 @default.
• W2024883161 countsByYear W20248831612018 @default.
• W2024883161 countsByYear W20248831612019 @default.
• W2024883161 countsByYear W20248831612020 @default.
• W2024883161 countsByYear W20248831612021 @default.
• W2024883161 countsByYear W20248831612022 @default.
• W2024883161 countsByYear W20248831612023 @default.
• W2024883161 crossrefType "journal-article" @default.
• W2024883161 hasAuthorship W2024883161A5039129582 @default.
• W2024883161 hasAuthorship W2024883161A5050253703 @default.
• W2024883161 hasAuthorship W2024883161A5058916083 @default.
• W2024883161 hasAuthorship W2024883161A5079037154 @default.
• W2024883161 hasBestOaLocation W20248831611 @default.
• W2024883161 hasConcept C134018914 @default.
• W2024883161 hasConcept C180526460 @default.
• W2024883161 hasConcept C181199279 @default.
• W2024883161 hasConcept C184235292 @default.
• W2024883161 hasConcept C185592680 @default.
• W2024883161 hasConcept C20251656 @default.
• W2024883161 hasConcept C24998067 @default.
• W2024883161 hasConcept C2776780712 @default.
• W2024883161 hasConcept C2780124434 @default.
• W2024883161 hasConcept C55493867 @default.
• W2024883161 hasConcept C86803240 @default.
• W2024883161 hasConcept C95444343 @default.
• W2024883161 hasConcept C97029542 @default.
• W2024883161 hasConceptScore W2024883161C134018914 @default.
• W2024883161 hasConceptScore W2024883161C180526460 @default.
• W2024883161 hasConceptScore W2024883161C181199279 @default.
• W2024883161 hasConceptScore W2024883161C184235292 @default.
• W2024883161 hasConceptScore W2024883161C185592680 @default.
• W2024883161 hasConceptScore W2024883161C20251656 @default.
• W2024883161 hasConceptScore W2024883161C24998067 @default.
• W2024883161 hasConceptScore W2024883161C2776780712 @default.
• W2024883161 hasConceptScore W2024883161C2780124434 @default.
• W2024883161 hasConceptScore W2024883161C55493867 @default.
• W2024883161 hasConceptScore W2024883161C86803240 @default.
• W2024883161 hasConceptScore W2024883161C95444343 @default.
• W2024883161 hasConceptScore W2024883161C97029542 @default.
• W2024883161 hasIssue "34" @default.
• W2024883161 hasLocation W20248831611 @default.
• W2024883161 hasOpenAccess W2024883161 @default.
• W2024883161 hasPrimaryLocation W20248831611 @default.
• W2024883161 hasRelatedWork W1497946234 @default.
• W2024883161 hasRelatedWork W1981934602 @default.
• W2024883161 hasRelatedWork W2017342497 @default.
• W2024883161 hasRelatedWork W2022630818 @default.
• W2024883161 hasRelatedWork W2031315554 @default.

• next