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- W2024883847 abstract "Approximately 0.14μ mol of hematoporphyrin derivative (a preparation made by treating hematoporphyrin with sulfuric acid-acetic acid) per μ mol of phospholipids was included in the lipid phase of reverse-phase evaporated liposomes which were composed of 4μ mol of phosphatidylcholine, 1 μ mol of phosphatidylglycerol, 5 μ mol of cholesterol and 1 μ mol of α-tocopherol. Treatment of mouse carcinoma FM3A cells with liposomes of the above composition which encapsulated 25 mm methotrexate, a water-soluble antifolate drug, inhibited cell multiplication completely whereas the same amount of the drug encapsulate in liposomes that were devoid of hematoporphyrin derivative and α-tocopherol did not affect cell growth. Of the constituents of the hematoporphyrin derivative, O,O′-diacetylhematoporphyrin was the most effective in raising the efficacy of delivery of aqueous materials into FM3A cells." @default.
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- W2024883847 date "1987-01-01" @default.
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- W2024883847 title "Inhibition of multiplication of mouse carcinoma FM3A cells by methotrexateencapsulated in liposomes that contain hematoporphyrin derivative in the membrane." @default.
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- W2024883847 doi "https://doi.org/10.1271/bbb1961.51.1277" @default.
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