FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024884562> ?p ?o ?g. }

• W2024884562 endingPage "915" @default.
• W2024884562 startingPage "908" @default.
• W2024884562 abstract "Cyclooxygenase (COX), the rate-limiting enzyme in prostaglandins (PG) synthesis, exists in at least two isoforms, COX-1 and COX-2. COX-2 plays an important role in carcinogenesis, and overexpression may increase proliferation, inhibit apoptosis, and enhance the invasiveness of breast cancer cells. Polymorphisms in the regulatory regions of the COX-2 gene may influence function and/or expression and contribute to interindividual variability in susceptibility to cancer. In this study three variants (−1195G/A and −765G/C in the promoter and 8473C/T in 3′UTR) of COX-2 were examined for correlation with breast cancer risk. A case-control study of 615 histologically confirmed breast cancer patients and 643 cancer-free controls frequency-matched for age were selected. Logistic regression analyses revealed that no overall significant associations were detected in the single-locus analysis between three polymorphisms of COX-2 and the risk of breast cancer. However, a significantly increased risk of breast cancer was associated with the combined genotypes containing “more than 3 variant alleles”' (adjusted OR = 1.37, 95% CI 1.01–1.84) compared with the combined genotypes with “0–3 variant alleles.” Haplotype analyses showed that haplotypes A−1195G−765T8473 and A−1195C−765T8473 were significantly associated with breast cancer risk (OR = 1.20, 95% CI 1.01–1.43 for A−1195G−765T8473; OR = 9.16, 95% CI 1.14–73.51 for A−1195C−765T8473) compared with the most common haplotype, G−1195G−765T8473. These findings indicate that these three variants in the regulatory regions of COX-2 may contribute to the etiology of breast cancer." @default.
• W2024884562 created "2016-06-24" @default.
• W2024884562 creator A5000196513 @default.
• W2024884562 creator A5000219612 @default.
• W2024884562 creator A5001453048 @default.
• W2024884562 creator A5004031758 @default.
• W2024884562 creator A5010979264 @default.
• W2024884562 creator A5012629684 @default.
• W2024884562 creator A5013452441 @default.
• W2024884562 creator A5030014001 @default.
• W2024884562 creator A5032100785 @default.
• W2024884562 creator A5043839973 @default.
• W2024884562 creator A5048992699 @default.
• W2024884562 creator A5066497348 @default.
• W2024884562 creator A5078734134 @default.
• W2024884562 creator A5084213516 @default.
• W2024884562 creator A5089209583 @default.
• W2024884562 date "2007-04-30" @default.
• W2024884562 modified "2023-10-18" @default.
• W2024884562 title "Functional Polymorphisms in the Cyclooxygenase 2 (COX-2) Gene and Risk of Breast Cancer in a Chinese Population" @default.
• W2024884562 cites W1597654508 @default.
• W2024884562 cites W1648593433 @default.
• W2024884562 cites W180197682 @default.
• W2024884562 cites W1962449772 @default.
• W2024884562 cites W1965314708 @default.
• W2024884562 cites W1971160226 @default.
• W2024884562 cites W1972504351 @default.
• W2024884562 cites W1987293829 @default.
• W2024884562 cites W2003436829 @default.
• W2024884562 cites W2004942960 @default.
• W2024884562 cites W2015254298 @default.
• W2024884562 cites W2018548355 @default.
• W2024884562 cites W2029941300 @default.
• W2024884562 cites W2038301005 @default.
• W2024884562 cites W2039577616 @default.
• W2024884562 cites W2039774384 @default.
• W2024884562 cites W2045016464 @default.
• W2024884562 cites W2060736868 @default.
• W2024884562 cites W2067608498 @default.
• W2024884562 cites W2075421196 @default.
• W2024884562 cites W2087281763 @default.
• W2024884562 cites W2095495874 @default.
• W2024884562 cites W2102201914 @default.
• W2024884562 cites W2107833029 @default.
• W2024884562 cites W2109808592 @default.
• W2024884562 cites W2111439621 @default.
• W2024884562 cites W2118283054 @default.
• W2024884562 cites W2127558096 @default.
• W2024884562 cites W2130833596 @default.
• W2024884562 cites W2145149010 @default.
• W2024884562 cites W2147025231 @default.
• W2024884562 cites W2150966393 @default.
• W2024884562 cites W2155062341 @default.
• W2024884562 cites W2156729894 @default.
• W2024884562 cites W2159973565 @default.
• W2024884562 cites W2164597973 @default.
• W2024884562 cites W2182373673 @default.
• W2024884562 doi "https://doi.org/10.1080/15287390701289966" @default.
• W2024884562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17479405" @default.
• W2024884562 hasPublicationYear "2007" @default.
• W2024884562 type Work @default.
• W2024884562 sameAs 2024884562 @default.
• W2024884562 citedByCount "45" @default.
• W2024884562 countsByYear W20248845622012 @default.
• W2024884562 countsByYear W20248845622013 @default.
• W2024884562 countsByYear W20248845622014 @default.
• W2024884562 countsByYear W20248845622015 @default.
• W2024884562 countsByYear W20248845622016 @default.
• W2024884562 countsByYear W20248845622017 @default.
• W2024884562 countsByYear W20248845622018 @default.
• W2024884562 countsByYear W20248845622019 @default.
• W2024884562 countsByYear W20248845622020 @default.
• W2024884562 crossrefType "journal-article" @default.
• W2024884562 hasAuthorship W2024884562A5000196513 @default.
• W2024884562 hasAuthorship W2024884562A5000219612 @default.
• W2024884562 hasAuthorship W2024884562A5001453048 @default.
• W2024884562 hasAuthorship W2024884562A5004031758 @default.
• W2024884562 hasAuthorship W2024884562A5010979264 @default.
• W2024884562 hasAuthorship W2024884562A5012629684 @default.
• W2024884562 hasAuthorship W2024884562A5013452441 @default.
• W2024884562 hasAuthorship W2024884562A5030014001 @default.
• W2024884562 hasAuthorship W2024884562A5032100785 @default.
• W2024884562 hasAuthorship W2024884562A5043839973 @default.
• W2024884562 hasAuthorship W2024884562A5048992699 @default.
• W2024884562 hasAuthorship W2024884562A5066497348 @default.
• W2024884562 hasAuthorship W2024884562A5078734134 @default.
• W2024884562 hasAuthorship W2024884562A5084213516 @default.
• W2024884562 hasAuthorship W2024884562A5089209583 @default.
• W2024884562 hasConcept C104317684 @default.
• W2024884562 hasConcept C121608353 @default.
• W2024884562 hasConcept C126322002 @default.
• W2024884562 hasConcept C135763542 @default.
• W2024884562 hasConcept C143998085 @default.
• W2024884562 hasConcept C180754005 @default.
• W2024884562 hasConcept C197754878 @default.
• W2024884562 hasConcept C502942594 @default.
• W2024884562 hasConcept C50382708 @default.
• W2024884562 hasConcept C530470458 @default.

• next