Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024884913> ?p ?o ?g. }
- W2024884913 endingPage "639" @default.
- W2024884913 startingPage "629" @default.
- W2024884913 abstract "The 3' enhancer of the T cell receptor alpha-chain (TCR alpha) gene directs the tissue- and stage-specific expression and V(D)J recombination of this gene locus. Using an in vitro system that reproduces TCR alpha enhancer activity efficiently, we show that long-range promoter-enhancer regulation requires a T cell-specific repressor complex and is sensitive to DNA topology. In this system, the enhancer functions to derepress the promoter on supercoiled, but not relaxed, templates. We find that the TCR alpha promoter is inactivated by a repressor complex that contains the architectural protein HMG I/Y. In the absence of this repressor complex, expression of the TCR alpha gene is completely independent of the 3' enhancer and DNA topology. The interaction of the T cell-restricted protein LEF-1 with the TCR alpha enhancer is required for promoter derepression. In this system, the TCR alpha enhancer increases the number of active promoters rather than the rate of transcription. Thus, long-range enhancers function in a distinct manner from promoters and provide the regulatory link between repressors, DNA topology, and gene activity." @default.
- W2024884913 created "2016-06-24" @default.
- W2024884913 creator A5048532228 @default.
- W2024884913 creator A5086736164 @default.
- W2024884913 date "1997-03-01" @default.
- W2024884913 modified "2023-09-25" @default.
- W2024884913 title "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro." @default.
- W2024884913 cites W1560668197 @default.
- W2024884913 cites W1596401901 @default.
- W2024884913 cites W1631475273 @default.
- W2024884913 cites W1773515121 @default.
- W2024884913 cites W183830646 @default.
- W2024884913 cites W1905881288 @default.
- W2024884913 cites W1964064521 @default.
- W2024884913 cites W1966156883 @default.
- W2024884913 cites W1966443347 @default.
- W2024884913 cites W1974210893 @default.
- W2024884913 cites W1985596446 @default.
- W2024884913 cites W1995232523 @default.
- W2024884913 cites W1997767982 @default.
- W2024884913 cites W2015944075 @default.
- W2024884913 cites W2018494368 @default.
- W2024884913 cites W2028263033 @default.
- W2024884913 cites W2029245541 @default.
- W2024884913 cites W2032069520 @default.
- W2024884913 cites W2035135369 @default.
- W2024884913 cites W2039420678 @default.
- W2024884913 cites W2041317251 @default.
- W2024884913 cites W2042344054 @default.
- W2024884913 cites W2058462189 @default.
- W2024884913 cites W2060769308 @default.
- W2024884913 cites W2063083243 @default.
- W2024884913 cites W2063957799 @default.
- W2024884913 cites W2083065209 @default.
- W2024884913 cites W2090610011 @default.
- W2024884913 cites W2091905001 @default.
- W2024884913 cites W211080140 @default.
- W2024884913 cites W2130002948 @default.
- W2024884913 cites W2147156824 @default.
- W2024884913 cites W2152336037 @default.
- W2024884913 cites W2167974691 @default.
- W2024884913 cites W2173817007 @default.
- W2024884913 cites W2302993874 @default.
- W2024884913 cites W2401367987 @default.
- W2024884913 cites W2428905324 @default.
- W2024884913 doi "https://doi.org/10.1101/gad.11.5.629" @default.
- W2024884913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9119227" @default.
- W2024884913 hasPublicationYear "1997" @default.
- W2024884913 type Work @default.
- W2024884913 sameAs 2024884913 @default.
- W2024884913 citedByCount "37" @default.
- W2024884913 countsByYear W20248849132013 @default.
- W2024884913 countsByYear W20248849132016 @default.
- W2024884913 crossrefType "journal-article" @default.
- W2024884913 hasAuthorship W2024884913A5048532228 @default.
- W2024884913 hasAuthorship W2024884913A5086736164 @default.
- W2024884913 hasBestOaLocation W20248849131 @default.
- W2024884913 hasConcept C101762097 @default.
- W2024884913 hasConcept C104317684 @default.
- W2024884913 hasConcept C111936080 @default.
- W2024884913 hasConcept C138885662 @default.
- W2024884913 hasConcept C150194340 @default.
- W2024884913 hasConcept C153911025 @default.
- W2024884913 hasConcept C158448853 @default.
- W2024884913 hasConcept C179926584 @default.
- W2024884913 hasConcept C186310378 @default.
- W2024884913 hasConcept C21784809 @default.
- W2024884913 hasConcept C41895202 @default.
- W2024884913 hasConcept C54355233 @default.
- W2024884913 hasConcept C62944979 @default.
- W2024884913 hasConcept C73766848 @default.
- W2024884913 hasConcept C86339819 @default.
- W2024884913 hasConcept C86803240 @default.
- W2024884913 hasConceptScore W2024884913C101762097 @default.
- W2024884913 hasConceptScore W2024884913C104317684 @default.
- W2024884913 hasConceptScore W2024884913C111936080 @default.
- W2024884913 hasConceptScore W2024884913C138885662 @default.
- W2024884913 hasConceptScore W2024884913C150194340 @default.
- W2024884913 hasConceptScore W2024884913C153911025 @default.
- W2024884913 hasConceptScore W2024884913C158448853 @default.
- W2024884913 hasConceptScore W2024884913C179926584 @default.
- W2024884913 hasConceptScore W2024884913C186310378 @default.
- W2024884913 hasConceptScore W2024884913C21784809 @default.
- W2024884913 hasConceptScore W2024884913C41895202 @default.
- W2024884913 hasConceptScore W2024884913C54355233 @default.
- W2024884913 hasConceptScore W2024884913C62944979 @default.
- W2024884913 hasConceptScore W2024884913C73766848 @default.
- W2024884913 hasConceptScore W2024884913C86339819 @default.
- W2024884913 hasConceptScore W2024884913C86803240 @default.
- W2024884913 hasIssue "5" @default.
- W2024884913 hasLocation W20248849131 @default.
- W2024884913 hasLocation W20248849132 @default.
- W2024884913 hasOpenAccess W2024884913 @default.
- W2024884913 hasPrimaryLocation W20248849131 @default.
- W2024884913 hasRelatedWork W1526973908 @default.
- W2024884913 hasRelatedWork W1830661192 @default.
- W2024884913 hasRelatedWork W2017956702 @default.
- W2024884913 hasRelatedWork W2024884913 @default.