Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024885145> ?p ?o ?g. }
- W2024885145 endingPage "2188" @default.
- W2024885145 startingPage "2174" @default.
- W2024885145 abstract "Arsenic trioxide exhibits antiproliferative, antiangiogenic and proapoptotic activity in cancer cells, and many genes associated with these responses are regulated by specificity protein (Sp) transcription factors. Treatment of cancer cells derived from urologic (bladder and prostate) and gastrointestinal (pancreas and colon) tumors with arsenic trioxide demonstrated that these cells exhibited differential responsiveness to the antiproliferative effects of this agent and this paralleled their differential repression of Sp1, Sp3 and Sp4 proteins in the same cell lines. Using arsenic trioxide-responsive KU7 and non-responsive 253JB-V bladder cancer cells as models, we show that in KU7 cells, ≤ 5 μM arsenic trioxide decreased Sp1, Sp3 and Sp4 and several Sp-dependent genes and responses including cyclin D1, epidermal growth factor receptor, bcl-2, survivin and vascular endothelial growth factor, whereas at concentrations up to 15 μM, minimal effects were observed in 253JB-V cells. Arsenic trioxide also inhibited tumor growth in athymic mice bearing KU7 cells as xenografts, and expression of Sp1, Sp3 and Sp4 was significantly decreased. Inhibitors of oxidative stress such as glutathione or dithiothreitol protected KU7 cells from arsenic trioxide-induced antiproliferative activity and Sp repression, whereas glutathione depletion sensitized 253JB-V cells to arsenic trioxide. Mechanistic studies suggested that arsenic trioxide-dependent downregulation of Sp and Sp-dependent genes was due to decreased mitochondrial membrane potential and induction of reactive oxygen species, and the role of peroxides in mediating these responses was confirmed using hydrogen peroxide." @default.
- W2024885145 created "2016-06-24" @default.
- W2024885145 creator A5012026287 @default.
- W2024885145 creator A5036119110 @default.
- W2024885145 creator A5036575223 @default.
- W2024885145 creator A5045907629 @default.
- W2024885145 creator A5050083954 @default.
- W2024885145 creator A5064099505 @default.
- W2024885145 creator A5067325195 @default.
- W2024885145 date "2010-08-01" @default.
- W2024885145 modified "2023-10-17" @default.
- W2024885145 title "Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth" @default.
- W2024885145 cites W1503272125 @default.
- W2024885145 cites W1603904020 @default.
- W2024885145 cites W1966597938 @default.
- W2024885145 cites W1969499993 @default.
- W2024885145 cites W1970923300 @default.
- W2024885145 cites W1972025137 @default.
- W2024885145 cites W1974839297 @default.
- W2024885145 cites W1978368975 @default.
- W2024885145 cites W1979256395 @default.
- W2024885145 cites W1980952563 @default.
- W2024885145 cites W1981044274 @default.
- W2024885145 cites W1981243565 @default.
- W2024885145 cites W1985485371 @default.
- W2024885145 cites W1996272511 @default.
- W2024885145 cites W1996349284 @default.
- W2024885145 cites W2007593968 @default.
- W2024885145 cites W2010432253 @default.
- W2024885145 cites W2011136667 @default.
- W2024885145 cites W2016403221 @default.
- W2024885145 cites W2017162950 @default.
- W2024885145 cites W2019350797 @default.
- W2024885145 cites W2023695651 @default.
- W2024885145 cites W2030476891 @default.
- W2024885145 cites W2043534420 @default.
- W2024885145 cites W2047327660 @default.
- W2024885145 cites W2049938816 @default.
- W2024885145 cites W2070412642 @default.
- W2024885145 cites W2082291497 @default.
- W2024885145 cites W2085343734 @default.
- W2024885145 cites W2086564382 @default.
- W2024885145 cites W2094105923 @default.
- W2024885145 cites W2097322288 @default.
- W2024885145 cites W2101801393 @default.
- W2024885145 cites W2105814326 @default.
- W2024885145 cites W2121529913 @default.
- W2024885145 cites W2125467210 @default.
- W2024885145 cites W2128753121 @default.
- W2024885145 cites W2133935930 @default.
- W2024885145 cites W2136752130 @default.
- W2024885145 cites W2142423276 @default.
- W2024885145 cites W2145628407 @default.
- W2024885145 cites W2150395434 @default.
- W2024885145 cites W2164986039 @default.
- W2024885145 cites W2170241782 @default.
- W2024885145 cites W2184391500 @default.
- W2024885145 cites W66419860 @default.
- W2024885145 doi "https://doi.org/10.1016/j.yexcr.2010.04.027" @default.
- W2024885145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2900380" @default.
- W2024885145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20435036" @default.
- W2024885145 hasPublicationYear "2010" @default.
- W2024885145 type Work @default.
- W2024885145 sameAs 2024885145 @default.
- W2024885145 citedByCount "76" @default.
- W2024885145 countsByYear W20248851452012 @default.
- W2024885145 countsByYear W20248851452013 @default.
- W2024885145 countsByYear W20248851452014 @default.
- W2024885145 countsByYear W20248851452015 @default.
- W2024885145 countsByYear W20248851452016 @default.
- W2024885145 countsByYear W20248851452017 @default.
- W2024885145 countsByYear W20248851452018 @default.
- W2024885145 countsByYear W20248851452019 @default.
- W2024885145 countsByYear W20248851452020 @default.
- W2024885145 countsByYear W20248851452021 @default.
- W2024885145 countsByYear W20248851452022 @default.
- W2024885145 countsByYear W20248851452023 @default.
- W2024885145 crossrefType "journal-article" @default.
- W2024885145 hasAuthorship W2024885145A5012026287 @default.
- W2024885145 hasAuthorship W2024885145A5036119110 @default.
- W2024885145 hasAuthorship W2024885145A5036575223 @default.
- W2024885145 hasAuthorship W2024885145A5045907629 @default.
- W2024885145 hasAuthorship W2024885145A5050083954 @default.
- W2024885145 hasAuthorship W2024885145A5064099505 @default.
- W2024885145 hasAuthorship W2024885145A5067325195 @default.
- W2024885145 hasBestOaLocation W20248851452 @default.
- W2024885145 hasConcept C104317684 @default.
- W2024885145 hasConcept C121608353 @default.
- W2024885145 hasConcept C127561419 @default.
- W2024885145 hasConcept C153911025 @default.
- W2024885145 hasConcept C181199279 @default.
- W2024885145 hasConcept C190283241 @default.
- W2024885145 hasConcept C2775975398 @default.
- W2024885145 hasConcept C2776151105 @default.
- W2024885145 hasConcept C2777824588 @default.
- W2024885145 hasConcept C2780352672 @default.
- W2024885145 hasConcept C2780386689 @default.
- W2024885145 hasConcept C48349386 @default.