Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024888031> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2024888031 endingPage "342" @default.
- W2024888031 startingPage "338" @default.
- W2024888031 abstract "The binding of [3H]N-methyl scopolamine (NMS) to muscarinic binding sites in rat forebrain was compared in two types of preparations: homogenates and slide-mounted sections. Under standard assay conditions, [3H]NMS bound to the muscarinic binding site with an apparent Kd that was almost one order of magnitude lower in homogenates (Kd = 0.15 nM) than sections (Kd = 1.25 nM). In addition, the muscarinic agonist carbachol inhibited [3H]NMS binding more effectively in homogenates (Ki = 5 microM) than sections (Ki = 100 microM). The higher Kd observed in sections was dependent upon the thickness of the section since the apparent Kd decreased as the thickness of the section was reduced. A slower equilibration rate may account, in part, for the higher apparent Kd seen in thicker sections. The results support previous evidence that certain ligands exhibit different binding profiles in homogenate and section preparations." @default.
- W2024888031 created "2016-06-24" @default.
- W2024888031 creator A5035103174 @default.
- W2024888031 creator A5055438971 @default.
- W2024888031 creator A5069941327 @default.
- W2024888031 creator A5089753548 @default.
- W2024888031 date "1986-02-01" @default.
- W2024888031 modified "2023-09-26" @default.
- W2024888031 title "Features of ligand binding in homogenate and section preparations" @default.
- W2024888031 cites W1971699435 @default.
- W2024888031 cites W2035914292 @default.
- W2024888031 cites W2042936373 @default.
- W2024888031 cites W2065545044 @default.
- W2024888031 cites W2070575104 @default.
- W2024888031 cites W2082355403 @default.
- W2024888031 cites W2084968056 @default.
- W2024888031 cites W2412575900 @default.
- W2024888031 cites W4293247451 @default.
- W2024888031 doi "https://doi.org/10.1016/0006-8993(86)91314-4" @default.
- W2024888031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3697689" @default.
- W2024888031 hasPublicationYear "1986" @default.
- W2024888031 type Work @default.
- W2024888031 sameAs 2024888031 @default.
- W2024888031 citedByCount "8" @default.
- W2024888031 crossrefType "journal-article" @default.
- W2024888031 hasAuthorship W2024888031A5035103174 @default.
- W2024888031 hasAuthorship W2024888031A5055438971 @default.
- W2024888031 hasAuthorship W2024888031A5069941327 @default.
- W2024888031 hasAuthorship W2024888031A5089753548 @default.
- W2024888031 hasConcept C107824862 @default.
- W2024888031 hasConcept C116569031 @default.
- W2024888031 hasConcept C12554922 @default.
- W2024888031 hasConcept C170493617 @default.
- W2024888031 hasConcept C185592680 @default.
- W2024888031 hasConcept C2778988552 @default.
- W2024888031 hasConcept C33789571 @default.
- W2024888031 hasConcept C55493867 @default.
- W2024888031 hasConcept C71240020 @default.
- W2024888031 hasConcept C86803240 @default.
- W2024888031 hasConceptScore W2024888031C107824862 @default.
- W2024888031 hasConceptScore W2024888031C116569031 @default.
- W2024888031 hasConceptScore W2024888031C12554922 @default.
- W2024888031 hasConceptScore W2024888031C170493617 @default.
- W2024888031 hasConceptScore W2024888031C185592680 @default.
- W2024888031 hasConceptScore W2024888031C2778988552 @default.
- W2024888031 hasConceptScore W2024888031C33789571 @default.
- W2024888031 hasConceptScore W2024888031C55493867 @default.
- W2024888031 hasConceptScore W2024888031C71240020 @default.
- W2024888031 hasConceptScore W2024888031C86803240 @default.
- W2024888031 hasIssue "1-2" @default.
- W2024888031 hasLocation W20248880311 @default.
- W2024888031 hasLocation W20248880312 @default.
- W2024888031 hasOpenAccess W2024888031 @default.
- W2024888031 hasPrimaryLocation W20248880311 @default.
- W2024888031 hasRelatedWork W1847954504 @default.
- W2024888031 hasRelatedWork W1982475468 @default.
- W2024888031 hasRelatedWork W1991678804 @default.
- W2024888031 hasRelatedWork W1995086001 @default.
- W2024888031 hasRelatedWork W2025619082 @default.
- W2024888031 hasRelatedWork W2028825888 @default.
- W2024888031 hasRelatedWork W2041031649 @default.
- W2024888031 hasRelatedWork W2170629275 @default.
- W2024888031 hasRelatedWork W2435262008 @default.
- W2024888031 hasRelatedWork W2981051885 @default.
- W2024888031 hasVolume "366" @default.
- W2024888031 isParatext "false" @default.
- W2024888031 isRetracted "false" @default.
- W2024888031 magId "2024888031" @default.
- W2024888031 workType "article" @default.