FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024888982> ?p ?o ?g. }

• W2024888982 endingPage "238" @default.
• W2024888982 startingPage "230" @default.
• W2024888982 abstract "The N-methyl-d-aspartate (NMDA) receptor-induced apoptosis is implicated in the pathological mechanisms of neural tissues, increasing the release of reactive oxygen species (ROS), resulting in a type of apoptotic cell death called excitotoxicity. Although intrinsic mechanisms to remove ROS, such as antioxidant enzymes, are provided by the tissue, the association between NMDA-induced excitotoxicity and antioxidative enzymes is not well understood. In this study, we focused on superoxide dismutase 1 (SOD1), an antioxidant enzyme, and investigated the role of SOD1 in the NMDA-induced neuronal cell death in the retina. NMDA was intravitreally injected into wild-type (WT) and SOD1 total knock-out (SOD1-deficient) mice. The number of TUNEL-positive cells in the retinal ganglion cell layer (GCL) and inner nuclear layer (INL) counted in the retinal sections and flatmount retinas were significantly higher in the SOD1-deficient mice than the WT mice after NMDA injection. Visual function assessed by dark-adapted electroretinogram (ERG) showed that the amplitudes of a-wave, b-wave, and oscillatory potential 2 were significantly reduced in the NMDA-injected SOD1-deficient mice. The level of ROS in the GCL and INL, measured using dihydroethidium, and the number of positive cells for γ-H2AX, a marker for DNA double strand breaks, and 8-OHdG, a marker for DNA oxidation, in the GCL were significantly increased in the SOD1-deficient mice after NMDA injection. We also measured mRNA and protein levels of SOD1 and SOD2 in the retina of WT mice, to find that mRNA and protein levels of SOD1, but not SOD2, were significantly reduced after NMDA injection. SOD1 deficiency exacerbated NMDA-induced damage to the inner retinal neurons, and NMDA reduced SOD1 levels in the retina of WT mice. Therefore, SOD1 protected retinal neurons against NMDA-induced retinal neurotoxicity, and NMDA-induced SOD1 reduction may be involved in neuronal vulnerability to excitotoxicity." @default.
• W2024888982 created "2016-06-24" @default.
• W2024888982 creator A5000405522 @default.
• W2024888982 creator A5018091647 @default.
• W2024888982 creator A5061193116 @default.
• W2024888982 creator A5069084864 @default.
• W2024888982 creator A5078664015 @default.
• W2024888982 date "2013-10-01" @default.
• W2024888982 modified "2023-09-24" @default.
• W2024888982 title "Neuroprotective role of superoxide dismutase 1 in retinal ganglion cells and inner nuclear layer cells against N-methyl-d-aspartate-induced cytotoxicity" @default.
• W2024888982 cites W1822557399 @default.
• W2024888982 cites W1842261381 @default.
• W2024888982 cites W1978255681 @default.
• W2024888982 cites W1978348298 @default.
• W2024888982 cites W1994148925 @default.
• W2024888982 cites W2004658509 @default.
• W2024888982 cites W2006732788 @default.
• W2024888982 cites W2007448480 @default.
• W2024888982 cites W2014746376 @default.
• W2024888982 cites W2020569812 @default.
• W2024888982 cites W2021227237 @default.
• W2024888982 cites W2023522106 @default.
• W2024888982 cites W2025295875 @default.
• W2024888982 cites W2027973956 @default.
• W2024888982 cites W2033963948 @default.
• W2024888982 cites W2038295164 @default.
• W2024888982 cites W2044387885 @default.
• W2024888982 cites W2047766745 @default.
• W2024888982 cites W2051796263 @default.
• W2024888982 cites W2055751128 @default.
• W2024888982 cites W2060410234 @default.
• W2024888982 cites W2066583147 @default.
• W2024888982 cites W2071391964 @default.
• W2024888982 cites W2093195138 @default.
• W2024888982 cites W2101861123 @default.
• W2024888982 cites W2119922704 @default.
• W2024888982 cites W2133569747 @default.
• W2024888982 cites W2133811137 @default.
• W2024888982 cites W2164226477 @default.
• W2024888982 cites W2166070786 @default.
• W2024888982 doi "https://doi.org/10.1016/j.exer.2013.07.002" @default.
• W2024888982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23856406" @default.
• W2024888982 hasPublicationYear "2013" @default.
• W2024888982 type Work @default.
• W2024888982 sameAs 2024888982 @default.
• W2024888982 citedByCount "16" @default.
• W2024888982 countsByYear W20248889822014 @default.
• W2024888982 countsByYear W20248889822015 @default.
• W2024888982 countsByYear W20248889822016 @default.
• W2024888982 countsByYear W20248889822017 @default.
• W2024888982 countsByYear W20248889822018 @default.
• W2024888982 countsByYear W20248889822019 @default.
• W2024888982 countsByYear W20248889822021 @default.
• W2024888982 crossrefType "journal-article" @default.
• W2024888982 hasAuthorship W2024888982A5000405522 @default.
• W2024888982 hasAuthorship W2024888982A5018091647 @default.
• W2024888982 hasAuthorship W2024888982A5061193116 @default.
• W2024888982 hasAuthorship W2024888982A5069084864 @default.
• W2024888982 hasAuthorship W2024888982A5078664015 @default.
• W2024888982 hasConcept C153911025 @default.
• W2024888982 hasConcept C169760540 @default.
• W2024888982 hasConcept C170493617 @default.
• W2024888982 hasConcept C185592680 @default.
• W2024888982 hasConcept C190283241 @default.
• W2024888982 hasConcept C196795494 @default.
• W2024888982 hasConcept C25498285 @default.
• W2024888982 hasConcept C2775838275 @default.
• W2024888982 hasConcept C2776108821 @default.
• W2024888982 hasConcept C2776151105 @default.
• W2024888982 hasConcept C2777093970 @default.
• W2024888982 hasConcept C2777506830 @default.
• W2024888982 hasConcept C2777615887 @default.
• W2024888982 hasConcept C2777624874 @default.
• W2024888982 hasConcept C2778231335 @default.
• W2024888982 hasConcept C2780188069 @default.
• W2024888982 hasConcept C2780827179 @default.
• W2024888982 hasConcept C2781012912 @default.
• W2024888982 hasConcept C31573885 @default.
• W2024888982 hasConcept C48349386 @default.
• W2024888982 hasConcept C55493867 @default.
• W2024888982 hasConcept C67018056 @default.
• W2024888982 hasConcept C86803240 @default.
• W2024888982 hasConcept C95444343 @default.
• W2024888982 hasConcept C98274493 @default.
• W2024888982 hasConceptScore W2024888982C153911025 @default.
• W2024888982 hasConceptScore W2024888982C169760540 @default.
• W2024888982 hasConceptScore W2024888982C170493617 @default.
• W2024888982 hasConceptScore W2024888982C185592680 @default.
• W2024888982 hasConceptScore W2024888982C190283241 @default.
• W2024888982 hasConceptScore W2024888982C196795494 @default.
• W2024888982 hasConceptScore W2024888982C25498285 @default.
• W2024888982 hasConceptScore W2024888982C2775838275 @default.
• W2024888982 hasConceptScore W2024888982C2776108821 @default.
• W2024888982 hasConceptScore W2024888982C2776151105 @default.
• W2024888982 hasConceptScore W2024888982C2777093970 @default.
• W2024888982 hasConceptScore W2024888982C2777506830 @default.
• W2024888982 hasConceptScore W2024888982C2777615887 @default.
• W2024888982 hasConceptScore W2024888982C2777624874 @default.

• next