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- W2024889065 endingPage "1269" @default.
- W2024889065 startingPage "1247" @default.
- W2024889065 abstract "Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair. Antioxid. Redox Signal. 12, 1247–1269. Introduction DNA-Repair Pathways Mammalian direct repair: O6-alkylguanine-DNA methyltransferase or O6-methylguanine-DNA methyltransferase Base-excision repair Nucleotide-excision repair Mismatch repair Nonhomologous DNA end-joining and homologous recombination General Redox Systems The thioredoxin system The glutaredoxin/glutathione system Roles of general redox systems The Redox Activity of APE1 Evolution of the redox function of APE1 Comparison of APE1 with other redox factors Mechanism of redox regulation by APE1 Transcription Factors Regulated by the Redox Activity of APE1 p53 AP-1 HIF-1α and hypoxia The Multifunctional APE1 and Redox Control Modulating APE1 Activities as a Cancer Therapeutic Approach APE1 redox inhibitors E3330 Other redox inhibitors APE1 repair inhibitors Chemoprevention, Redox Modulation, and DNA Repair Dietary antioxidants Ellagic acid Selenium Oltipraz Direct regulation of DNA repair by altered redox status of the cell Concluding Remarks" @default.
- W2024889065 created "2016-06-24" @default.
- W2024889065 creator A5018202347 @default.
- W2024889065 creator A5030886603 @default.
- W2024889065 creator A5041580310 @default.
- W2024889065 creator A5062363713 @default.
- W2024889065 date "2010-06-01" @default.
- W2024889065 modified "2023-10-16" @default.
- W2024889065 title "Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development" @default.
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