FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024889753> ?p ?o ?g. }

• W2024889753 endingPage "737" @default.
• W2024889753 startingPage "731" @default.
• W2024889753 abstract "Activation of Src, which has an intrinsic protein tyrosine kinase (PTK) activity, has been demonstrated in human solid tumors, such as colorectal and breast cancers. To investigate the role of activated Src in drug resistance, we evaluated the effect of v-src on the resistance to various anti-cancer drugs using v-src-transfected HAG-1 human gallbladder adenocarcinoma cells. Compared with parental or mock-transfected HAG-1 cells, v-src-transfected HAG/src3–1 cells showed a 3.5-fold resistance to cis-diamminedichloroplatinum (II) (CDDP) but not to doxorubicin, etoposide or 5-fluorouracil. By contrast, activated H-ras, which acts downstream of src, failed to induce resistance to either of these drugs. Furthermore, wortmannin, a phosphatidylinositol (PI) 3-kinase inhibitor, and H7, a protein kinase C (PKC) inhibitor, did not alter CDDP resistance. Evaluation of the kinetics of the removal of DNA interstrand cross-links (ICLs), measured by alkaline elution, showed a significant increase in this removal in HAG/src3–1 cells as compared with mock-transfected cells, though no differences were found in the formation of DNA ICLs between these cell lines. CDDP resistance in v-src-transfected cells was reversed, if not completely, by either herbimycin A or radicicol, specific inhibitors of Src-family PTKs, suggesting that Src tyrosine kinase activity induces CDDP resistance. Moreover, significant reduction in the repair of CDDP-induced DNA ICLs was observed upon treatment with radicicol. The intracellular glutathione content and mRNA expression of topoisomerase II and metallothionein were virtually identical between these cell lines, except for topoisomerase I mRNA. Our data strongly suggest that the ability of activated src, but not ras, to induce CDDP resistance is mediated by augmentation of DNA repair through Src to downstream signal-transduction pathways distinct from either the Ras, PI 3-kinase or PKC pathway. Int. J. Cancer 80:731–737, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2024889753 created "2016-06-24" @default.
• W2024889753 creator A5001341804 @default.
• W2024889753 creator A5017008708 @default.
• W2024889753 creator A5019835015 @default.
• W2024889753 creator A5069747635 @default.
• W2024889753 creator A5082131946 @default.
• W2024889753 date "1999-03-01" @default.
• W2024889753 modified "2023-10-03" @default.
• W2024889753 title "v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells" @default.
• W2024889753 cites W1557874430 @default.
• W2024889753 cites W1973454785 @default.
• W2024889753 cites W1974458329 @default.
• W2024889753 cites W1980327805 @default.
• W2024889753 cites W2003772907 @default.
• W2024889753 cites W2007064404 @default.
• W2024889753 cites W2008968721 @default.
• W2024889753 cites W2015333209 @default.
• W2024889753 cites W2030565228 @default.
• W2024889753 cites W2041337400 @default.
• W2024889753 cites W2046163031 @default.
• W2024889753 cites W2060199545 @default.
• W2024889753 cites W2061413260 @default.
• W2024889753 cites W2062381728 @default.
• W2024889753 cites W2063658280 @default.
• W2024889753 cites W2067424974 @default.
• W2024889753 cites W2078160913 @default.
• W2024889753 cites W2078767371 @default.
• W2024889753 cites W2080617731 @default.
• W2024889753 cites W2095156669 @default.
• W2024889753 cites W2121881330 @default.
• W2024889753 cites W2131552467 @default.
• W2024889753 cites W2325985806 @default.
• W2024889753 cites W2407373097 @default.
• W2024889753 doi "https://doi.org/10.1002/(sici)1097-0215(19990301)80:5<731::aid-ijc17>3.0.co;2-h" @default.
• W2024889753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10048975" @default.
• W2024889753 hasPublicationYear "1999" @default.
• W2024889753 type Work @default.
• W2024889753 sameAs 2024889753 @default.
• W2024889753 citedByCount "52" @default.
• W2024889753 countsByYear W20248897532012 @default.
• W2024889753 countsByYear W20248897532013 @default.
• W2024889753 countsByYear W20248897532014 @default.
• W2024889753 countsByYear W20248897532015 @default.
• W2024889753 countsByYear W20248897532017 @default.
• W2024889753 countsByYear W20248897532019 @default.
• W2024889753 countsByYear W20248897532023 @default.
• W2024889753 crossrefType "journal-article" @default.
• W2024889753 hasAuthorship W2024889753A5001341804 @default.
• W2024889753 hasAuthorship W2024889753A5017008708 @default.
• W2024889753 hasAuthorship W2024889753A5019835015 @default.
• W2024889753 hasAuthorship W2024889753A5069747635 @default.
• W2024889753 hasAuthorship W2024889753A5082131946 @default.
• W2024889753 hasBestOaLocation W20248897531 @default.
• W2024889753 hasConcept C108636557 @default.
• W2024889753 hasConcept C147897179 @default.
• W2024889753 hasConcept C153911025 @default.
• W2024889753 hasConcept C184235292 @default.
• W2024889753 hasConcept C202751555 @default.
• W2024889753 hasConcept C2776694085 @default.
• W2024889753 hasConcept C2778239845 @default.
• W2024889753 hasConcept C2778308172 @default.
• W2024889753 hasConcept C2780610907 @default.
• W2024889753 hasConcept C42362537 @default.
• W2024889753 hasConcept C502942594 @default.
• W2024889753 hasConcept C54009773 @default.
• W2024889753 hasConcept C54355233 @default.
• W2024889753 hasConcept C55493867 @default.
• W2024889753 hasConcept C62478195 @default.
• W2024889753 hasConcept C81885089 @default.
• W2024889753 hasConcept C86803240 @default.
• W2024889753 hasConceptScore W2024889753C108636557 @default.
• W2024889753 hasConceptScore W2024889753C147897179 @default.
• W2024889753 hasConceptScore W2024889753C153911025 @default.
• W2024889753 hasConceptScore W2024889753C184235292 @default.
• W2024889753 hasConceptScore W2024889753C202751555 @default.
• W2024889753 hasConceptScore W2024889753C2776694085 @default.
• W2024889753 hasConceptScore W2024889753C2778239845 @default.
• W2024889753 hasConceptScore W2024889753C2778308172 @default.
• W2024889753 hasConceptScore W2024889753C2780610907 @default.
• W2024889753 hasConceptScore W2024889753C42362537 @default.
• W2024889753 hasConceptScore W2024889753C502942594 @default.
• W2024889753 hasConceptScore W2024889753C54009773 @default.
• W2024889753 hasConceptScore W2024889753C54355233 @default.
• W2024889753 hasConceptScore W2024889753C55493867 @default.
• W2024889753 hasConceptScore W2024889753C62478195 @default.
• W2024889753 hasConceptScore W2024889753C81885089 @default.
• W2024889753 hasConceptScore W2024889753C86803240 @default.
• W2024889753 hasIssue "5" @default.
• W2024889753 hasLocation W20248897531 @default.
• W2024889753 hasLocation W20248897532 @default.
• W2024889753 hasOpenAccess W2024889753 @default.
• W2024889753 hasPrimaryLocation W20248897531 @default.
• W2024889753 hasRelatedWork W2003413845 @default.
• W2024889753 hasRelatedWork W2017768282 @default.
• W2024889753 hasRelatedWork W2040998738 @default.
• W2024889753 hasRelatedWork W2047255798 @default.
• W2024889753 hasRelatedWork W2053393868 @default.

• next