Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024890764> ?p ?o ?g. }
- W2024890764 endingPage "71" @default.
- W2024890764 startingPage "60" @default.
- W2024890764 abstract "•EPAC1 desensitizes leptin signaling in hypothalamus. •EPAC2 facilitates GSIS in response to GLP-1 and obesity induced insulin resistance. •Small molecule EPAC modulators have therapeutic potential for obesity and T2DM. The pleiotropic second-messenger cAMP plays a crucial role in mediating the effects of various hormones on metabolism. The major intracellular functions of cAMP are transduced by protein kinase A (PKA) and by exchange proteins directly activated by cAMP (EPACs). The latter act as guanine-nucleotide exchange factors for the RAS-like small G proteins Rap1 and Rap2. Although the role of PKA in regulating energy balance has been extensively studied, the impact of EPACs remains relatively enigmatic. This review summarizes recent genetic and pharmacological studies concerning EPAC involvement in glucose homeostasis and energy balance via the regulation of leptin and insulin signaling pathways. In addition, the development of small-molecule EPAC-specific modulators and their therapeutic potential for the treatment of diabetes and obesity are discussed. The pleiotropic second-messenger cAMP plays a crucial role in mediating the effects of various hormones on metabolism. The major intracellular functions of cAMP are transduced by protein kinase A (PKA) and by exchange proteins directly activated by cAMP (EPACs). The latter act as guanine-nucleotide exchange factors for the RAS-like small G proteins Rap1 and Rap2. Although the role of PKA in regulating energy balance has been extensively studied, the impact of EPACs remains relatively enigmatic. This review summarizes recent genetic and pharmacological studies concerning EPAC involvement in glucose homeostasis and energy balance via the regulation of leptin and insulin signaling pathways. In addition, the development of small-molecule EPAC-specific modulators and their therapeutic potential for the treatment of diabetes and obesity are discussed." @default.
- W2024890764 created "2016-06-24" @default.
- W2024890764 creator A5037359600 @default.
- W2024890764 creator A5064997314 @default.
- W2024890764 creator A5080619609 @default.
- W2024890764 date "2014-02-01" @default.
- W2024890764 modified "2023-09-27" @default.
- W2024890764 title "Cyclic AMP sensor EPAC proteins and energy homeostasis" @default.
- W2024890764 cites W1012070930 @default.
- W2024890764 cites W1511208409 @default.
- W2024890764 cites W1573925283 @default.
- W2024890764 cites W1585952967 @default.
- W2024890764 cites W1652203375 @default.
- W2024890764 cites W1653273172 @default.
- W2024890764 cites W1885709862 @default.
- W2024890764 cites W1964771859 @default.
- W2024890764 cites W1967182435 @default.
- W2024890764 cites W1968194659 @default.
- W2024890764 cites W1972748729 @default.
- W2024890764 cites W1973983376 @default.
- W2024890764 cites W1974947279 @default.
- W2024890764 cites W1977040622 @default.
- W2024890764 cites W1979957714 @default.
- W2024890764 cites W1983082230 @default.
- W2024890764 cites W1983286754 @default.
- W2024890764 cites W1983565569 @default.
- W2024890764 cites W1988909797 @default.
- W2024890764 cites W1990472520 @default.
- W2024890764 cites W1995375315 @default.
- W2024890764 cites W1995698227 @default.
- W2024890764 cites W1996683094 @default.
- W2024890764 cites W1996713062 @default.
- W2024890764 cites W1996800212 @default.
- W2024890764 cites W1998735059 @default.
- W2024890764 cites W2003946536 @default.
- W2024890764 cites W2009061745 @default.
- W2024890764 cites W2011571924 @default.
- W2024890764 cites W2017709986 @default.
- W2024890764 cites W2022430914 @default.
- W2024890764 cites W2022674028 @default.
- W2024890764 cites W2023075547 @default.
- W2024890764 cites W2027489564 @default.
- W2024890764 cites W2027683776 @default.
- W2024890764 cites W2030107946 @default.
- W2024890764 cites W2030817984 @default.
- W2024890764 cites W2033220684 @default.
- W2024890764 cites W2033401611 @default.
- W2024890764 cites W2036053907 @default.
- W2024890764 cites W2041028158 @default.
- W2024890764 cites W2042071773 @default.
- W2024890764 cites W2043625750 @default.
- W2024890764 cites W2043718702 @default.
- W2024890764 cites W2043908137 @default.
- W2024890764 cites W2046526895 @default.
- W2024890764 cites W2056383195 @default.
- W2024890764 cites W2056860785 @default.
- W2024890764 cites W2059683355 @default.
- W2024890764 cites W2059764720 @default.
- W2024890764 cites W2061505650 @default.
- W2024890764 cites W2067096633 @default.
- W2024890764 cites W2067242542 @default.
- W2024890764 cites W2068064315 @default.
- W2024890764 cites W2068769790 @default.
- W2024890764 cites W2069584884 @default.
- W2024890764 cites W2070506072 @default.
- W2024890764 cites W2078037416 @default.
- W2024890764 cites W2079053528 @default.
- W2024890764 cites W2079199039 @default.
- W2024890764 cites W2080508995 @default.
- W2024890764 cites W2081876438 @default.
- W2024890764 cites W2084548757 @default.
- W2024890764 cites W2089519239 @default.
- W2024890764 cites W2091650620 @default.
- W2024890764 cites W2093913323 @default.
- W2024890764 cites W2094751859 @default.
- W2024890764 cites W2097135764 @default.
- W2024890764 cites W2098593394 @default.
- W2024890764 cites W2099009658 @default.
- W2024890764 cites W2100816243 @default.
- W2024890764 cites W2101015984 @default.
- W2024890764 cites W2102649799 @default.
- W2024890764 cites W2104269617 @default.
- W2024890764 cites W2104521877 @default.
- W2024890764 cites W2105987351 @default.
- W2024890764 cites W2108613841 @default.
- W2024890764 cites W2109093140 @default.
- W2024890764 cites W2109532866 @default.
- W2024890764 cites W2115254012 @default.
- W2024890764 cites W2116127675 @default.
- W2024890764 cites W2118743996 @default.
- W2024890764 cites W2126312769 @default.
- W2024890764 cites W2127071047 @default.
- W2024890764 cites W2130166672 @default.
- W2024890764 cites W2130800855 @default.
- W2024890764 cites W2134644953 @default.
- W2024890764 cites W2136791012 @default.
- W2024890764 cites W2137137048 @default.
- W2024890764 cites W2138047939 @default.