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- W2024891661 abstract "Actin is one of the most conserved and versatile proteins capable of forming homopolymers and interacting with numerous other proteins in the cell. We performed an alanine mutagenesis scan covering the entire beta-actin molecule. Somewhat surprisingly, the majority of the mutants were capable of reaching a stable conformation. We tested the ability of these mutants to bind to various actin binding proteins, thereby mapping different interfaces with actin. Additionally, we tested their ability to copolymerize with alpha-actin in order to localize regions in actin that contact neighboring protomers in the filament. Hereby, we could discriminate between two existing models for filamentous actin and our data strongly support the right-handed double-stranded helix model. We present data corroborating this model in vivo. Mutants defective in copolymerization do not colocalize with the actin cytoskeleton and some impair its normal function, thereby disturbing cell shape." @default.
- W2024891661 created "2016-06-24" @default.
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- W2024891661 date "2003-10-01" @default.
- W2024891661 modified "2023-10-12" @default.
- W2024891661 title "Structural Plasticity of Functional Actin" @default.
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- W2024891661 doi "https://doi.org/10.1016/j.str.2003.09.002" @default.
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