FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024892304> ?p ?o ?g. }

• W2024892304 endingPage "7831" @default.
• W2024892304 startingPage "7824" @default.
• W2024892304 abstract "Several 11-ethyl-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-ones with varied functionality on the ethyl substituent have exhibited potent topoisomerase I (TOP1) targeting activity and antitumor activity. The influence of various polar substituents at the 2-position of the 11-ethyl substituent, including N-methylamine, N-isopropylamine, hydroxyl, and hydroxylamino groups, on TOP1-targeting activity and cytotoxicity was assessed. The N-methylamine and N-isopropylamine derivatives were also evaluated as antitumor agents in athymic nude mice with MDA-MB-435 human tumor xenografts. Both compounds were active as antitumor agents upon either parenteral or oral administration." @default.
• W2024892304 created "2016-06-24" @default.
• W2024892304 creator A5016600808 @default.
• W2024892304 creator A5022556834 @default.
• W2024892304 creator A5032798692 @default.
• W2024892304 creator A5052916385 @default.
• W2024892304 creator A5057145998 @default.
• W2024892304 creator A5072757128 @default.
• W2024892304 creator A5077511640 @default.
• W2024892304 date "2008-08-01" @default.
• W2024892304 modified "2023-09-27" @default.
• W2024892304 title "Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31)" @default.
• W2024892304 cites W1966831567 @default.
• W2024892304 cites W1976526749 @default.
• W2024892304 cites W1982075384 @default.
• W2024892304 cites W1985349868 @default.
• W2024892304 cites W1990991016 @default.
• W2024892304 cites W2008902935 @default.
• W2024892304 cites W2016254453 @default.
• W2024892304 cites W2018557806 @default.
• W2024892304 cites W2045116568 @default.
• W2024892304 cites W2053784378 @default.
• W2024892304 cites W2063495162 @default.
• W2024892304 cites W2082081271 @default.
• W2024892304 cites W2084246932 @default.
• W2024892304 cites W2090637879 @default.
• W2024892304 cites W2102345056 @default.
• W2024892304 cites W2103489107 @default.
• W2024892304 cites W2113007993 @default.
• W2024892304 cites W2136553882 @default.
• W2024892304 cites W2003967829 @default.
• W2024892304 doi "https://doi.org/10.1016/j.bmc.2008.06.046" @default.
• W2024892304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18676151" @default.
• W2024892304 hasPublicationYear "2008" @default.
• W2024892304 type Work @default.
• W2024892304 sameAs 2024892304 @default.
• W2024892304 citedByCount "14" @default.
• W2024892304 countsByYear W20248923042012 @default.
• W2024892304 countsByYear W20248923042014 @default.
• W2024892304 countsByYear W20248923042018 @default.
• W2024892304 countsByYear W20248923042019 @default.
• W2024892304 countsByYear W20248923042020 @default.
• W2024892304 countsByYear W20248923042022 @default.
• W2024892304 crossrefType "journal-article" @default.
• W2024892304 hasAuthorship W2024892304A5016600808 @default.
• W2024892304 hasAuthorship W2024892304A5022556834 @default.
• W2024892304 hasAuthorship W2024892304A5032798692 @default.
• W2024892304 hasAuthorship W2024892304A5052916385 @default.
• W2024892304 hasAuthorship W2024892304A5057145998 @default.
• W2024892304 hasAuthorship W2024892304A5072757128 @default.
• W2024892304 hasAuthorship W2024892304A5077511640 @default.
• W2024892304 hasConcept C109316439 @default.
• W2024892304 hasConcept C147897179 @default.
• W2024892304 hasConcept C178790620 @default.
• W2024892304 hasConcept C185592680 @default.
• W2024892304 hasConcept C202751555 @default.
• W2024892304 hasConcept C2778689049 @default.
• W2024892304 hasConcept C2778969155 @default.
• W2024892304 hasConcept C2780263894 @default.
• W2024892304 hasConcept C2780760878 @default.
• W2024892304 hasConcept C2781206959 @default.
• W2024892304 hasConcept C55493867 @default.
• W2024892304 hasConcept C71240020 @default.
• W2024892304 hasConcept C71924100 @default.
• W2024892304 hasConcept C90150868 @default.
• W2024892304 hasConcept C98274493 @default.
• W2024892304 hasConceptScore W2024892304C109316439 @default.
• W2024892304 hasConceptScore W2024892304C147897179 @default.
• W2024892304 hasConceptScore W2024892304C178790620 @default.
• W2024892304 hasConceptScore W2024892304C185592680 @default.
• W2024892304 hasConceptScore W2024892304C202751555 @default.
• W2024892304 hasConceptScore W2024892304C2778689049 @default.
• W2024892304 hasConceptScore W2024892304C2778969155 @default.
• W2024892304 hasConceptScore W2024892304C2780263894 @default.
• W2024892304 hasConceptScore W2024892304C2780760878 @default.
• W2024892304 hasConceptScore W2024892304C2781206959 @default.
• W2024892304 hasConceptScore W2024892304C55493867 @default.
• W2024892304 hasConceptScore W2024892304C71240020 @default.
• W2024892304 hasConceptScore W2024892304C71924100 @default.
• W2024892304 hasConceptScore W2024892304C90150868 @default.
• W2024892304 hasConceptScore W2024892304C98274493 @default.
• W2024892304 hasIssue "16" @default.
• W2024892304 hasLocation W20248923041 @default.
• W2024892304 hasLocation W20248923042 @default.
• W2024892304 hasOpenAccess W2024892304 @default.
• W2024892304 hasPrimaryLocation W20248923041 @default.
• W2024892304 hasRelatedWork W1173959259 @default.
• W2024892304 hasRelatedWork W2010735377 @default.
• W2024892304 hasRelatedWork W2024892304 @default.
• W2024892304 hasRelatedWork W2034656065 @default.
• W2024892304 hasRelatedWork W2053784378 @default.
• W2024892304 hasRelatedWork W2082081271 @default.
• W2024892304 hasRelatedWork W2091165641 @default.
• W2024892304 hasRelatedWork W2103673127 @default.
• W2024892304 hasRelatedWork W2145675608 @default.
• W2024892304 hasRelatedWork W2950589408 @default.
• W2024892304 hasVolume "16" @default.
• W2024892304 isParatext "false" @default.

• next