FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024892377> ?p ?o ?g. }

• W2024892377 endingPage "605" @default.
• W2024892377 startingPage "593" @default.
• W2024892377 abstract "Proteolipids are abundant integral membrane proteins, initially described as structural proteins of CNS myelin. More recently, two neuronal proteins related to proteolipid protein (PLP), termed M6A and M6B, were identified, suggesting a common function of proteolipids in oligodendrocytes and neurons. We have analyzed the X-linked M6B gene and discovered an unexpected complexity of protein isoforms. Two promoters and alternative exons yield at least eight M6B proteins and polypeptides, differentially expressed in neurons and oligodendrocytes. Six isoforms are tetraspan membrane proteins that differ by highly conserved amino- and carboxy-terminal domains, termed α, β, ψ, and ω. In MDCK cells, the β-domain of M6B stabilizes tetraspan proteolipids at the cell surface, whereas non-β isoforms are more abundant in intracellular compartments. Cotransfection experiments suggest a physical interaction of M6B and mutant PLP, when retained in the endoplasmic reticulum, that may also contribute to oligodendrocyte dysfunction in Pelizaeus–Merzbacher disease." @default.
• W2024892377 created "2016-06-24" @default.
• W2024892377 creator A5008892103 @default.
• W2024892377 creator A5027472835 @default.
• W2024892377 creator A5031085916 @default.
• W2024892377 creator A5038465445 @default.
• W2024892377 creator A5044498878 @default.
• W2024892377 date "2001-12-01" @default.
• W2024892377 modified "2023-10-17" @default.
• W2024892377 title "Multiple Splice Isoforms of Proteolipid M6B in Neurons and Oligodendrocytes" @default.
• W2024892377 cites W1543011513 @default.
• W2024892377 cites W1606017151 @default.
• W2024892377 cites W1966801664 @default.
• W2024892377 cites W1977687052 @default.
• W2024892377 cites W1977707793 @default.
• W2024892377 cites W1979815209 @default.
• W2024892377 cites W1995050445 @default.
• W2024892377 cites W2001888569 @default.
• W2024892377 cites W2002871398 @default.
• W2024892377 cites W2012069056 @default.
• W2024892377 cites W2014084841 @default.
• W2024892377 cites W2031990262 @default.
• W2024892377 cites W2036567890 @default.
• W2024892377 cites W2038965715 @default.
• W2024892377 cites W2045243921 @default.
• W2024892377 cites W2047833547 @default.
• W2024892377 cites W2048607748 @default.
• W2024892377 cites W2067308634 @default.
• W2024892377 cites W2067340278 @default.
• W2024892377 cites W2068502629 @default.
• W2024892377 cites W2077103473 @default.
• W2024892377 cites W2083092470 @default.
• W2024892377 cites W2089405081 @default.
• W2024892377 cites W2090205264 @default.
• W2024892377 cites W2094369068 @default.
• W2024892377 cites W2097849969 @default.
• W2024892377 cites W2101392697 @default.
• W2024892377 cites W2110062889 @default.
• W2024892377 cites W2114546421 @default.
• W2024892377 cites W2126968890 @default.
• W2024892377 cites W2130861575 @default.
• W2024892377 cites W2142695196 @default.
• W2024892377 cites W2153909879 @default.
• W2024892377 cites W2172027287 @default.
• W2024892377 cites W28489994 @default.
• W2024892377 doi "https://doi.org/10.1006/mcne.2001.1044" @default.
• W2024892377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11749036" @default.
• W2024892377 hasPublicationYear "2001" @default.
• W2024892377 type Work @default.
• W2024892377 sameAs 2024892377 @default.
• W2024892377 citedByCount "52" @default.
• W2024892377 countsByYear W20248923772012 @default.
• W2024892377 countsByYear W20248923772013 @default.
• W2024892377 countsByYear W20248923772014 @default.
• W2024892377 countsByYear W20248923772015 @default.
• W2024892377 countsByYear W20248923772017 @default.
• W2024892377 countsByYear W20248923772018 @default.
• W2024892377 countsByYear W20248923772019 @default.
• W2024892377 countsByYear W20248923772020 @default.
• W2024892377 countsByYear W20248923772022 @default.
• W2024892377 countsByYear W20248923772023 @default.
• W2024892377 crossrefType "journal-article" @default.
• W2024892377 hasAuthorship W2024892377A5008892103 @default.
• W2024892377 hasAuthorship W2024892377A5027472835 @default.
• W2024892377 hasAuthorship W2024892377A5031085916 @default.
• W2024892377 hasAuthorship W2024892377A5038465445 @default.
• W2024892377 hasAuthorship W2024892377A5044498878 @default.
• W2024892377 hasConcept C104317684 @default.
• W2024892377 hasConcept C143065580 @default.
• W2024892377 hasConcept C144647389 @default.
• W2024892377 hasConcept C158617107 @default.
• W2024892377 hasConcept C161200384 @default.
• W2024892377 hasConcept C169760540 @default.
• W2024892377 hasConcept C194583182 @default.
• W2024892377 hasConcept C2776985911 @default.
• W2024892377 hasConcept C2777426553 @default.
• W2024892377 hasConcept C2778609137 @default.
• W2024892377 hasConcept C2780876595 @default.
• W2024892377 hasConcept C41625074 @default.
• W2024892377 hasConcept C529278444 @default.
• W2024892377 hasConcept C53345823 @default.
• W2024892377 hasConcept C55493867 @default.
• W2024892377 hasConcept C7821365 @default.
• W2024892377 hasConcept C86803240 @default.
• W2024892377 hasConcept C95444343 @default.
• W2024892377 hasConceptScore W2024892377C104317684 @default.
• W2024892377 hasConceptScore W2024892377C143065580 @default.
• W2024892377 hasConceptScore W2024892377C144647389 @default.
• W2024892377 hasConceptScore W2024892377C158617107 @default.
• W2024892377 hasConceptScore W2024892377C161200384 @default.
• W2024892377 hasConceptScore W2024892377C169760540 @default.
• W2024892377 hasConceptScore W2024892377C194583182 @default.
• W2024892377 hasConceptScore W2024892377C2776985911 @default.
• W2024892377 hasConceptScore W2024892377C2777426553 @default.
• W2024892377 hasConceptScore W2024892377C2778609137 @default.
• W2024892377 hasConceptScore W2024892377C2780876595 @default.
• W2024892377 hasConceptScore W2024892377C41625074 @default.
• W2024892377 hasConceptScore W2024892377C529278444 @default.

• next