FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024892700> ?p ?o ?g. }

• W2024892700 endingPage "442" @default.
• W2024892700 startingPage "439" @default.
• W2024892700 abstract "We studied the actions of receptor-activating peptide analogues (PAR4APs), modeled on the proteolytically-revealed tethered ligand sequence of murine proteinase-activated receptor-4 (PAR4), in a rat platelet aggregation assay. The PAR4APs GYPGKF-NH2 (GY-NH2) and AYPGKF-NH2 (AY-NH2) were able to cause aggregation with EC50 values of about 40 microM and 15 microM, respectively. The reverse human PAR4 sequence (VQGPYG-NH2, YG-NH2) and the PAR1AP SFLLR-NH2, did not cause aggregation. In contrast, trans-cinnamoyl-YPGKF-NH2 (tcY-NH2) did not cause aggregation but blocked aggregation caused by GY-NH2, AY-NH2, and thrombin without affecting ADP-mediated aggregation. We conclude that in contrast to the PAR1AP, the PAR4APs GY-NH2 and AY-NH2 activate rat platelets via a PAR4-related receptor and that peptide analogues modeled on the PAR4 tethered activating sequence can serve as useful agonist and antagonist probes for assessing the consequence of activating PAR4 either by PAR4APs or thrombin in rat tissue preparations." @default.
• W2024892700 created "2016-06-24" @default.
• W2024892700 creator A5045627202 @default.
• W2024892700 creator A5077297886 @default.
• W2024892700 date "2001-05-01" @default.
• W2024892700 modified "2023-10-11" @default.
• W2024892700 title "Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides" @default.
• W2024892700 cites W158700254 @default.
• W2024892700 cites W1623022149 @default.
• W2024892700 cites W1658287483 @default.
• W2024892700 cites W180211874 @default.
• W2024892700 cites W1811402656 @default.
• W2024892700 cites W1958081034 @default.
• W2024892700 cites W1964499190 @default.
• W2024892700 cites W1998899308 @default.
• W2024892700 cites W2007781471 @default.
• W2024892700 cites W2017672336 @default.
• W2024892700 cites W2033852349 @default.
• W2024892700 cites W2050739759 @default.
• W2024892700 cites W2058742965 @default.
• W2024892700 cites W2070602928 @default.
• W2024892700 cites W2081753893 @default.
• W2024892700 cites W2087408808 @default.
• W2024892700 cites W2126058021 @default.
• W2024892700 cites W2127850909 @default.
• W2024892700 doi "https://doi.org/10.1139/y01-013" @default.
• W2024892700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11405248" @default.
• W2024892700 hasPublicationYear "2001" @default.
• W2024892700 type Work @default.
• W2024892700 sameAs 2024892700 @default.
• W2024892700 citedByCount "60" @default.
• W2024892700 countsByYear W20248927002012 @default.
• W2024892700 countsByYear W20248927002013 @default.
• W2024892700 countsByYear W20248927002014 @default.
• W2024892700 countsByYear W20248927002015 @default.
• W2024892700 countsByYear W20248927002016 @default.
• W2024892700 countsByYear W20248927002017 @default.
• W2024892700 countsByYear W20248927002018 @default.
• W2024892700 countsByYear W20248927002019 @default.
• W2024892700 countsByYear W20248927002020 @default.
• W2024892700 countsByYear W20248927002021 @default.
• W2024892700 countsByYear W20248927002022 @default.
• W2024892700 crossrefType "journal-article" @default.
• W2024892700 hasAuthorship W2024892700A5045627202 @default.
• W2024892700 hasAuthorship W2024892700A5077297886 @default.
• W2024892700 hasConcept C149577978 @default.
• W2024892700 hasConcept C170493617 @default.
• W2024892700 hasConcept C185592680 @default.
• W2024892700 hasConcept C202751555 @default.
• W2024892700 hasConcept C203014093 @default.
• W2024892700 hasConcept C2776885963 @default.
• W2024892700 hasConcept C2777292125 @default.
• W2024892700 hasConcept C2778886182 @default.
• W2024892700 hasConcept C2778938600 @default.
• W2024892700 hasConcept C2779281246 @default.
• W2024892700 hasConcept C2993802102 @default.
• W2024892700 hasConcept C3018697912 @default.
• W2024892700 hasConcept C55493867 @default.
• W2024892700 hasConcept C86803240 @default.
• W2024892700 hasConcept C89560881 @default.
• W2024892700 hasConcept C95444343 @default.
• W2024892700 hasConcept C98274493 @default.
• W2024892700 hasConceptScore W2024892700C149577978 @default.
• W2024892700 hasConceptScore W2024892700C170493617 @default.
• W2024892700 hasConceptScore W2024892700C185592680 @default.
• W2024892700 hasConceptScore W2024892700C202751555 @default.
• W2024892700 hasConceptScore W2024892700C203014093 @default.
• W2024892700 hasConceptScore W2024892700C2776885963 @default.
• W2024892700 hasConceptScore W2024892700C2777292125 @default.
• W2024892700 hasConceptScore W2024892700C2778886182 @default.
• W2024892700 hasConceptScore W2024892700C2778938600 @default.
• W2024892700 hasConceptScore W2024892700C2779281246 @default.
• W2024892700 hasConceptScore W2024892700C2993802102 @default.
• W2024892700 hasConceptScore W2024892700C3018697912 @default.
• W2024892700 hasConceptScore W2024892700C55493867 @default.
• W2024892700 hasConceptScore W2024892700C86803240 @default.
• W2024892700 hasConceptScore W2024892700C89560881 @default.
• W2024892700 hasConceptScore W2024892700C95444343 @default.
• W2024892700 hasConceptScore W2024892700C98274493 @default.
• W2024892700 hasIssue "5" @default.
• W2024892700 hasLocation W20248927001 @default.
• W2024892700 hasLocation W20248927002 @default.
• W2024892700 hasOpenAccess W2024892700 @default.
• W2024892700 hasPrimaryLocation W20248927001 @default.
• W2024892700 hasRelatedWork W1999403270 @default.
• W2024892700 hasRelatedWork W2037637243 @default.
• W2024892700 hasRelatedWork W2084742840 @default.
• W2024892700 hasRelatedWork W2137577167 @default.
• W2024892700 hasRelatedWork W2204279058 @default.
• W2024892700 hasRelatedWork W2290856779 @default.
• W2024892700 hasRelatedWork W2315992852 @default.
• W2024892700 hasRelatedWork W2418765770 @default.
• W2024892700 hasRelatedWork W2463317919 @default.
• W2024892700 hasRelatedWork W4298202184 @default.
• W2024892700 hasVolume "79" @default.
• W2024892700 isParatext "false" @default.
• W2024892700 isRetracted "false" @default.
• W2024892700 magId "2024892700" @default.

• next