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- W2024893104 abstract "Most tumours arise from a single normal cell through a sequential evolutionary process of mutation and selection. Tumours are initiated by escaping non-immune surveillance, which includes defective DNA repair, epigenetic gene alternation, resistance to apoptosis and loss of intercellular contact inhibition. Tumour cells harbour mutations in a number of critical genes that provide selective advantages at various stages during the evolution of the tumour. The tumour cells that circumvent the tumour suppressor mechanisms of the non-immune surveillance process are edited by the immune system, resulting in the selection of a resistant tumour variant. The selection of the tumour cell is further shaped by its interactions with cells and other factors in its microenvironment. Tumour evolution is thought to adhere to Darwinian principles by escaping both non-immune (intrinsic) and immune (extrinsic) responses against self-altered tumour cells. At end-stage, tumours have escaped both non-immune and immune surveillance with increased threshold of apoptosis. Combination therapy has been proposed, by exploring the non-immune and immune suppressive nature of the tumour, and has been found to have a therapeutic efficiency on tumour regression as compared with monotherapies. The combination of immunotherapy and other different modalities, especially vaccines, with conventional anticancer therapies with optimized dosage and scheduling can offer synergistic antitumour effects. Here, we focus on the mechanism of tumour evolution and its implication in combination therapy." @default.
- W2024893104 created "2016-06-24" @default.
- W2024893104 creator A5043450835 @default.
- W2024893104 creator A5055574140 @default.
- W2024893104 creator A5068972811 @default.
- W2024893104 date "2010-04-08" @default.
- W2024893104 modified "2023-09-26" @default.
- W2024893104 title "Tumour escape mechanisms and their therapeutic implications in combination tumour therapy" @default.
- W2024893104 cites W1487122896 @default.
- W2024893104 cites W1498187417 @default.
- W2024893104 cites W1522277376 @default.
- W2024893104 cites W1527985047 @default.
- W2024893104 cites W1552528612 @default.
- W2024893104 cites W1557286178 @default.
- W2024893104 cites W1560571961 @default.
- W2024893104 cites W1793388556 @default.
- W2024893104 cites W1966657187 @default.
- W2024893104 cites W1968893400 @default.
- W2024893104 cites W1970533032 @default.
- W2024893104 cites W1971878785 @default.
- W2024893104 cites W1973579337 @default.
- W2024893104 cites W1975929837 @default.
- W2024893104 cites W1982596539 @default.
- W2024893104 cites W1984484036 @default.
- W2024893104 cites W1984832220 @default.
- W2024893104 cites W1988301036 @default.
- W2024893104 cites W1988365805 @default.
- W2024893104 cites W1991753815 @default.
- W2024893104 cites W1995483670 @default.
- W2024893104 cites W1995483885 @default.
- W2024893104 cites W1999763927 @default.
- W2024893104 cites W2001037779 @default.
- W2024893104 cites W2002915111 @default.
- W2024893104 cites W2003946492 @default.
- W2024893104 cites W2004911979 @default.
- W2024893104 cites W2005542290 @default.
- W2024893104 cites W2010024040 @default.
- W2024893104 cites W2014909608 @default.
- W2024893104 cites W2016910978 @default.
- W2024893104 cites W2016983859 @default.
- W2024893104 cites W2019214729 @default.
- W2024893104 cites W2019430935 @default.
- W2024893104 cites W2023653499 @default.
- W2024893104 cites W2025701563 @default.
- W2024893104 cites W2029299243 @default.
- W2024893104 cites W2032106677 @default.
- W2024893104 cites W2032530158 @default.
- W2024893104 cites W2033601733 @default.
- W2024893104 cites W2034269086 @default.
- W2024893104 cites W2038158718 @default.
- W2024893104 cites W2044764392 @default.
- W2024893104 cites W2045246330 @default.
- W2024893104 cites W2048084134 @default.
- W2024893104 cites W2049347064 @default.
- W2024893104 cites W2054764151 @default.
- W2024893104 cites W2056590164 @default.
- W2024893104 cites W2063192133 @default.
- W2024893104 cites W2064920472 @default.
- W2024893104 cites W2067931945 @default.
- W2024893104 cites W2068834940 @default.
- W2024893104 cites W2073573249 @default.
- W2024893104 cites W2077717752 @default.
- W2024893104 cites W2078965027 @default.
- W2024893104 cites W2081894694 @default.
- W2024893104 cites W2083826495 @default.
- W2024893104 cites W2090222871 @default.
- W2024893104 cites W2090748725 @default.
- W2024893104 cites W2095046039 @default.
- W2024893104 cites W2102508255 @default.
- W2024893104 cites W2109513968 @default.
- W2024893104 cites W2113510389 @default.
- W2024893104 cites W2116169737 @default.
- W2024893104 cites W2116460444 @default.
- W2024893104 cites W2117280704 @default.
- W2024893104 cites W2117681951 @default.
- W2024893104 cites W2119174775 @default.
- W2024893104 cites W2121626779 @default.
- W2024893104 cites W2122411952 @default.
- W2024893104 cites W2123558100 @default.
- W2024893104 cites W2125988618 @default.
- W2024893104 cites W2128380182 @default.
- W2024893104 cites W2130211103 @default.
- W2024893104 cites W2131451077 @default.
- W2024893104 cites W2131874142 @default.
- W2024893104 cites W2133000461 @default.
- W2024893104 cites W2134724142 @default.
- W2024893104 cites W2142052493 @default.
- W2024893104 cites W2142302700 @default.
- W2024893104 cites W2144037068 @default.
- W2024893104 cites W2146530991 @default.
- W2024893104 cites W2148702138 @default.
- W2024893104 cites W2149260641 @default.
- W2024893104 cites W2155189639 @default.
- W2024893104 cites W2157962067 @default.
- W2024893104 cites W2160276388 @default.
- W2024893104 cites W2162117160 @default.
- W2024893104 cites W2171709048 @default.
- W2024893104 cites W2316380619 @default.