Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024894183> ?p ?o ?g. }
- W2024894183 endingPage "1000" @default.
- W2024894183 startingPage "994" @default.
- W2024894183 abstract "Intracerebral injection of ibotenate in newborn rodents produces brain damage that mimics that of infants with cerebral palsy. Because maternal infection may contribute to brain injury in preterm infants, we investigated brain damage after maternal inflammation and postnatal ibotenate treatment in a rat model of cerebral palsy. Pregnant rats were injected intraperitoneally with lipopolysaccharide at Days 19 and 20 of gestation. Neonates were given intracerebral injections of ibotenate at postnatal Day 4 and were then killed at Day 9. Lesion sizes were measured by cresyl violet staining, and microglial activation, astrogliosis, and myelination were evaluated by immunohistochemistry. The lipopolysaccharide groups had larger cortical and white matter lesions than the control group; they also had significantly greater microglial activation and astrogliosis and less white matter myelination in the lesioned hemispheres compared with the controls. Thus, maternal endotoxin exposure may affect prenatal development of the offspring and modulate the subsequent development of excitotoxic brain lesions. These results demonstrate the critical influence of prenatal immune events on neonatal central nervous system vulnerability and provide a model for studying the pathophysiology of cerebral damage in preterm infants and, specifically, the interplay between brain inflammation and excitotoxicity." @default.
- W2024894183 created "2016-06-24" @default.
- W2024894183 creator A5016876419 @default.
- W2024894183 creator A5024933639 @default.
- W2024894183 creator A5028207329 @default.
- W2024894183 creator A5033474449 @default.
- W2024894183 creator A5046340755 @default.
- W2024894183 creator A5061255679 @default.
- W2024894183 date "2008-10-01" @default.
- W2024894183 modified "2023-09-28" @default.
- W2024894183 title "Antenatal Bacterial Endotoxin Sensitizes the Immature Rat Brain to Postnatal Excitotoxic Injury" @default.
- W2024894183 cites W1583433785 @default.
- W2024894183 cites W1936688462 @default.
- W2024894183 cites W1964039180 @default.
- W2024894183 cites W1965064543 @default.
- W2024894183 cites W1970874907 @default.
- W2024894183 cites W1978924462 @default.
- W2024894183 cites W1981367767 @default.
- W2024894183 cites W1981383949 @default.
- W2024894183 cites W1993174038 @default.
- W2024894183 cites W2003710864 @default.
- W2024894183 cites W2006593236 @default.
- W2024894183 cites W2007322682 @default.
- W2024894183 cites W2007655172 @default.
- W2024894183 cites W2027914644 @default.
- W2024894183 cites W2040415483 @default.
- W2024894183 cites W2052783666 @default.
- W2024894183 cites W2057442927 @default.
- W2024894183 cites W2058572795 @default.
- W2024894183 cites W2066347230 @default.
- W2024894183 cites W2078538756 @default.
- W2024894183 cites W2086517182 @default.
- W2024894183 cites W2100290637 @default.
- W2024894183 cites W2100571830 @default.
- W2024894183 cites W2109342780 @default.
- W2024894183 cites W2126365703 @default.
- W2024894183 cites W2128637331 @default.
- W2024894183 cites W2132493492 @default.
- W2024894183 cites W2138924326 @default.
- W2024894183 cites W2141638391 @default.
- W2024894183 cites W2146317119 @default.
- W2024894183 cites W2155368784 @default.
- W2024894183 cites W2170398304 @default.
- W2024894183 cites W26913945 @default.
- W2024894183 cites W4233222285 @default.
- W2024894183 cites W4244942887 @default.
- W2024894183 cites W4248536872 @default.
- W2024894183 cites W4300542283 @default.
- W2024894183 cites W4367032812 @default.
- W2024894183 doi "https://doi.org/10.1097/nen.0b013e31818894a1" @default.
- W2024894183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18800008" @default.
- W2024894183 hasPublicationYear "2008" @default.
- W2024894183 type Work @default.
- W2024894183 sameAs 2024894183 @default.
- W2024894183 citedByCount "45" @default.
- W2024894183 countsByYear W20248941832012 @default.
- W2024894183 countsByYear W20248941832013 @default.
- W2024894183 countsByYear W20248941832014 @default.
- W2024894183 countsByYear W20248941832015 @default.
- W2024894183 countsByYear W20248941832016 @default.
- W2024894183 countsByYear W20248941832017 @default.
- W2024894183 countsByYear W20248941832018 @default.
- W2024894183 countsByYear W20248941832019 @default.
- W2024894183 countsByYear W20248941832020 @default.
- W2024894183 countsByYear W20248941832021 @default.
- W2024894183 countsByYear W20248941832022 @default.
- W2024894183 crossrefType "journal-article" @default.
- W2024894183 hasAuthorship W2024894183A5016876419 @default.
- W2024894183 hasAuthorship W2024894183A5024933639 @default.
- W2024894183 hasAuthorship W2024894183A5028207329 @default.
- W2024894183 hasAuthorship W2024894183A5033474449 @default.
- W2024894183 hasAuthorship W2024894183A5046340755 @default.
- W2024894183 hasAuthorship W2024894183A5061255679 @default.
- W2024894183 hasBestOaLocation W20248941831 @default.
- W2024894183 hasConcept C118552586 @default.
- W2024894183 hasConcept C126322002 @default.
- W2024894183 hasConcept C126838900 @default.
- W2024894183 hasConcept C134018914 @default.
- W2024894183 hasConcept C142724271 @default.
- W2024894183 hasConcept C143409427 @default.
- W2024894183 hasConcept C170493617 @default.
- W2024894183 hasConcept C2778376644 @default.
- W2024894183 hasConcept C2779234561 @default.
- W2024894183 hasConcept C2779421357 @default.
- W2024894183 hasConcept C2779740913 @default.
- W2024894183 hasConcept C2779965356 @default.
- W2024894183 hasConcept C2780123866 @default.
- W2024894183 hasConcept C2781012912 @default.
- W2024894183 hasConcept C2781156865 @default.
- W2024894183 hasConcept C2781192897 @default.
- W2024894183 hasConcept C2781458332 @default.
- W2024894183 hasConcept C529278444 @default.
- W2024894183 hasConcept C54355233 @default.
- W2024894183 hasConcept C61174792 @default.
- W2024894183 hasConcept C71924100 @default.
- W2024894183 hasConcept C74864618 @default.
- W2024894183 hasConcept C86803240 @default.
- W2024894183 hasConceptScore W2024894183C118552586 @default.