Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024897055> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2024897055 endingPage "39" @default.
- W2024897055 startingPage "33" @default.
- W2024897055 abstract "This study reports changes in the prevalence and outcome of Down's syndrome pregnancies within a 15-year period in a defined geographical population in the north of England. Cases of Down's syndrome in births and terminations of pregnancy occurring between 1985 and 1999, were identified from the Northern Congenital Abnormality Survey. The total prevalence for the 15 years was 15.2 per 10 000 births and terminations of pregnancy [95% CI 14.2, 16.2]. Total prevalence showed an upward trend over time, due largely to increasing maternal age. Sixty-seven per cent of cases resulted in live births, and the overall live birth prevalence was 10.3 per 10 000 live births [95% CI 9.4, 11.1]. The proportion of cases resulting in termination of pregnancy rose from 15% in 1985-89 to 38% in 1995-99; the rate of increase was greater in women aged < 35 years. Forty-five per cent of live born infants had an additional anomaly recorded. Survival at 1 year was 78% for those with an additional anomaly recorded, and 96% for those without. There was a non-significant trend towards improved survival in all infants with Down's syndrome, from 87% in 1985-94 to 92% in 1995-99. Despite increasing termination of Down's syndrome pregnancies resulting from the greater availability of antenatal screening and diagnosis, there has been no significant reduction in live birth prevalence. These infants have high rates of co-existing structural anomalies and are at high risk of death in the first year of life. There is a continuing need to address the reasons for poor survival for Down's syndrome infants, and to plan for their complex health and social care needs. These findings are useful for parents deciding on prenatal screening, as well as for clinicians and health service managers." @default.
- W2024897055 created "2016-06-24" @default.
- W2024897055 creator A5071598367 @default.
- W2024897055 creator A5074552203 @default.
- W2024897055 creator A5086921757 @default.
- W2024897055 date "2003-01-01" @default.
- W2024897055 modified "2023-10-14" @default.
- W2024897055 title "Down's syndrome: occurrence and outcome in the north of England, 1985-99" @default.
- W2024897055 cites W147716141 @default.
- W2024897055 cites W1971780199 @default.
- W2024897055 cites W1973591786 @default.
- W2024897055 cites W1973775128 @default.
- W2024897055 cites W1976141587 @default.
- W2024897055 cites W1987566551 @default.
- W2024897055 cites W1995198589 @default.
- W2024897055 cites W2031029620 @default.
- W2024897055 cites W2040904496 @default.
- W2024897055 cites W2061036940 @default.
- W2024897055 cites W2085636079 @default.
- W2024897055 cites W2090254559 @default.
- W2024897055 cites W2149745536 @default.
- W2024897055 cites W2168802143 @default.
- W2024897055 cites W2183532376 @default.
- W2024897055 cites W2320010444 @default.
- W2024897055 cites W2429396454 @default.
- W2024897055 cites W4230599058 @default.
- W2024897055 cites W4230607991 @default.
- W2024897055 cites W4242803038 @default.
- W2024897055 cites W4361745143 @default.
- W2024897055 doi "https://doi.org/10.1046/j.1365-3016.2003.00463.x" @default.
- W2024897055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12562470" @default.
- W2024897055 hasPublicationYear "2003" @default.
- W2024897055 type Work @default.
- W2024897055 sameAs 2024897055 @default.
- W2024897055 citedByCount "58" @default.
- W2024897055 countsByYear W20248970552012 @default.
- W2024897055 countsByYear W20248970552014 @default.
- W2024897055 countsByYear W20248970552015 @default.
- W2024897055 countsByYear W20248970552016 @default.
- W2024897055 countsByYear W20248970552018 @default.
- W2024897055 countsByYear W20248970552020 @default.
- W2024897055 countsByYear W20248970552022 @default.
- W2024897055 crossrefType "journal-article" @default.
- W2024897055 hasAuthorship W2024897055A5071598367 @default.
- W2024897055 hasAuthorship W2024897055A5074552203 @default.
- W2024897055 hasAuthorship W2024897055A5086921757 @default.
- W2024897055 hasConcept C118552586 @default.
- W2024897055 hasConcept C131872663 @default.
- W2024897055 hasConcept C144024400 @default.
- W2024897055 hasConcept C149923435 @default.
- W2024897055 hasConcept C187212893 @default.
- W2024897055 hasConcept C2778279030 @default.
- W2024897055 hasConcept C2779234561 @default.
- W2024897055 hasConcept C2779954681 @default.
- W2024897055 hasConcept C2908647359 @default.
- W2024897055 hasConcept C37512671 @default.
- W2024897055 hasConcept C518429986 @default.
- W2024897055 hasConcept C54355233 @default.
- W2024897055 hasConcept C71924100 @default.
- W2024897055 hasConcept C86803240 @default.
- W2024897055 hasConcept C99454951 @default.
- W2024897055 hasConceptScore W2024897055C118552586 @default.
- W2024897055 hasConceptScore W2024897055C131872663 @default.
- W2024897055 hasConceptScore W2024897055C144024400 @default.
- W2024897055 hasConceptScore W2024897055C149923435 @default.
- W2024897055 hasConceptScore W2024897055C187212893 @default.
- W2024897055 hasConceptScore W2024897055C2778279030 @default.
- W2024897055 hasConceptScore W2024897055C2779234561 @default.
- W2024897055 hasConceptScore W2024897055C2779954681 @default.
- W2024897055 hasConceptScore W2024897055C2908647359 @default.
- W2024897055 hasConceptScore W2024897055C37512671 @default.
- W2024897055 hasConceptScore W2024897055C518429986 @default.
- W2024897055 hasConceptScore W2024897055C54355233 @default.
- W2024897055 hasConceptScore W2024897055C71924100 @default.
- W2024897055 hasConceptScore W2024897055C86803240 @default.
- W2024897055 hasConceptScore W2024897055C99454951 @default.
- W2024897055 hasIssue "1" @default.
- W2024897055 hasLocation W20248970551 @default.
- W2024897055 hasLocation W20248970552 @default.
- W2024897055 hasOpenAccess W2024897055 @default.
- W2024897055 hasPrimaryLocation W20248970551 @default.
- W2024897055 hasRelatedWork W2024008300 @default.
- W2024897055 hasRelatedWork W2053951608 @default.
- W2024897055 hasRelatedWork W2109994796 @default.
- W2024897055 hasRelatedWork W2147096318 @default.
- W2024897055 hasRelatedWork W2352507830 @default.
- W2024897055 hasRelatedWork W2401739700 @default.
- W2024897055 hasRelatedWork W2793008352 @default.
- W2024897055 hasRelatedWork W2798199048 @default.
- W2024897055 hasRelatedWork W3046001131 @default.
- W2024897055 hasRelatedWork W3114540110 @default.
- W2024897055 hasVolume "17" @default.
- W2024897055 isParatext "false" @default.
- W2024897055 isRetracted "false" @default.
- W2024897055 magId "2024897055" @default.
- W2024897055 workType "article" @default.