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- W2024897326 abstract "Endocrine treatment of prostate cancer has been established for more than 5 decades. Focusing on immediate or short-term side effects, bilateral orchidectomy may cause psychological trauma, treatment with oral estrogens is combined with a high risk of severe cardiovascular complications, and the use of LH-RH agonists and antiandrogens as monotherapies or in combination may result in tumor flare, hot flashes, and gynecomastia. In recent years an increasing number of reports on anemia and/or osteoporosis related to endocrine treatment have been published. These side effects are regular and persistent after orchidectomy, or during treatment with LH-RH agonists, and are most often expressed with maximum androgen blockade. In contrast, anemia and/or osteoporosis are not reported with estrogen treatment or the use of nonsteroidal antiandrogens as a monotherapy regimen. Since many prostate cancer patients are treated hormonally for many years, control of Hb levels and bone mineral density before and after initiation of treatment at regular intervals is highly recommended as a standard of care." @default.
- W2024897326 created "2016-06-24" @default.
- W2024897326 creator A5001084590 @default.
- W2024897326 date "2000-01-01" @default.
- W2024897326 modified "2023-09-27" @default.
- W2024897326 title "Potential side-effects of endocrine treatment of long duration in prostate cancer" @default.
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- W2024897326 doi "https://doi.org/10.1002/1097-0045(2000)45:10+<38::aid-pros8>3.0.co;2-m" @default.
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