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- W2024900154 abstract "Poly(rI).poly(rC) induces a lytic reaction in interferon-treated mouse LM cells. We have attempted to determine whether the intracellular penetration of poly(rI).poly(rC) is a prerequisite for cell lysis and to gain some insight into the pathway followed. We found that poly(rI).poly(rC) coupled to Sepharose beads was unable to generate lysis of interferon-treated cells whereas the cells underwent lysis after microinjection of poly(rI).poly(rC). Some inhibitors of endocytosis were found to inhibit the development of the lytic reaction. Lysosomotropic amines or a low temperature (19 degrees C) blocked endocytosis of poly(rI).poly(rC) but did not prevent its uptake. The internalization of poly(rI).poly(rC) was energy-dependent and was blocked when sodium azide and 2-deoxyglucose were added simultaneously. We conclude that poly(rI).poly(rC) is internalized and reaches an acidic compartment before triggering the lytic reaction in the cell." @default.
- W2024900154 created "2016-06-24" @default.
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- W2024900154 date "1987-04-01" @default.
- W2024900154 modified "2023-09-25" @default.
- W2024900154 title "Requirement for Endocytosis of Poly(rI).Poly(rC) to Generate Toxicity on Interferon-treated LM Cells" @default.
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- W2024900154 doi "https://doi.org/10.1099/0022-1317-68-4-1125" @default.
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