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- W2024921878 abstract "Pittsburgh Compound B ([11C]PiB) is a specific positron emission tomography (PET) marker of cerebral amyloid deposits. Only few data with conflicting results have been published about the in vivo longitudinal changes of amyloid load in Alzheimer's disease patients and so far little is known about the factors that influence these changes. A group of 24 patients with probable AD, as defined by established clinical criteria and by an AD-typical pattern of tracer uptake in [18F]FDG-PET underwent [11C]PiB-PET examinations at baseline and after 24 months. The difference of amyloid load between examinations and the association with clinical and neurobiological variables was examined using a regions of interest (ROI) approach and voxel-based analyses. Cerebral [11C]PiB uptake ratio increased significantly by 3.92 % per year. While the increase occurred in all parts of the neocortex, no increase was detected in the archipallium. The increase was gene-dose-dependent to the number of apolipoprotein E (ApoE) ∊4 alleles. Progression of dementia symptoms were correlated to the [11C]PiB increase in numerous regions associated with cognition. The results of this study indicate that a measurable increase of amyloid deposition occurs in patients with AD during a relatively short interval of its clinical course. The amyloid aggregation rate has been found to be strongly dependent on ApoE-genotype, which may be particularly important for the evaluation of anti-amyloid drug treatment effects. Thus, this study further emphasizes the value of amyloid-plaque imaging as a marker of disease progression and a potential surrogate marker for anti-amyloid trials." @default.
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- W2024921878 date "2010-07-01" @default.
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- W2024921878 title "Progression of cerebral amyloid load in Alzheimer's disease is associated with the apolipoprotein E E-ε4 genotype" @default.
- W2024921878 doi "https://doi.org/10.1016/j.jalz.2010.05.963" @default.
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