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• W2024921886 abstract "Protein S is an anticoagulant cofactor of full-length tissue factor pathway inhibitor (TFPI) that facilitates optimal factor Xa-inhibition and efficient down-regulation of thrombin generation in plasma. Protein S and TFPI are constitutively active in plasma and therefore provide an effective anticoagulant barrier against unwanted procoagulant activity in the circulation. In this review, we describe the current status on how TFPI-activity depends on protein S, and show that TFPI and protein S are major regulators of thrombin generation both in the absence and presence of activated protein C (APC). As there is covariation of plasma TFPI and protein S levels both in health and in disease, these findings suggest that the risk of venous thrombosis associated with protein S deficiency states might be in part explained by the accompanying low plasma TFPI levels." @default.
• W2024921886 created "2016-06-24" @default.
• W2024921886 creator A5003992239 @default.
• W2024921886 creator A5015042844 @default.
• W2024921886 creator A5082526403 @default.
• W2024921886 creator A5087919219 @default.
• W2024921886 date "2009-07-01" @default.
• W2024921886 modified "2023-10-14" @default.
• W2024921886 title "Regulation of TFPI function by protein S" @default.
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• W2024921886 doi "https://doi.org/10.1111/j.1538-7836.2009.03363.x" @default.
• W2024921886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19630792" @default.
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