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• W2024923809 abstract "Summary 1.A study of atopic dermatitis in private practice in 100 consecutively encountered infants and children over a three-year period reveals equal distribution between sexes with onset in the first two years of life in 90 per cent. The dermatitis was exaggerated in the pollen seasons when due to pollen, and often in the fall to spring when due to foods, and at times to house dust and environmental allergens. Dermatitis was perennial in 67 per cent with exacerbation during the spring and summer in 28 per cent. 2.The majority of patients exhibited other allergic manifestations, and a family history of allergy was obtained in 65 per cent of cases. 3.Food, inhalant, drug, and infectant allergies were considered possible causes. Food and inhalant allergies proved to be most important. A detailed history, physical examination, and cautious skin testing by both scratch and intradermal methods were the most effective diagnostic procedures. Scratch or puncture testing with important ingestants and inhalants was performed on all patients, and intradermal testing reserved for those suspected of being inhalant sensitive, especially when environmental control alone was not effective. Intradermal testing was performed by our modification of the serial titration technique of Rinkel. 4.Elimination diets were used in 95 per cent of cases for study of suspected food allergy. Environmental control was instituted in 55 per cent, inhalant desensitization given in 58 per cent, and vaccine therapy for secondary infection in 10 per cent. Our recently devised filter tent was used for the study and treatment of inhalant allergy in 12 per cent. 5.Food allergy was the sole cause of atopic dermatitis in 44 per cent, and was associated with inhalant allergy in 41 per cent. Inhalant allergy alone was responsible in 15 per cent, and in association with food allergy in 41 per cent. The frequency of inhalant sensitivity increases after the first year. 6.The utilization of extremely weak dilutions of inhalant antigens is stressed. In the majority of inhalant sensitive individuals an appropriate initial desensitizing dose could be approximated by the serial dilution titration technique. However clinical titration alone was occasionally necessary. 7.The control of symptoms especially pruritus is discussed. 8.With study and treatment of specific causes, good or excellent results were obtained in 84 per cent of cases. These good results emphasize the importance of thorough and experienced study and treatment of inhalant allergy along with food allergy. In some cases the degree of relief at the end of the first year was only 50 to 75 per cent, and increased significantly during the second year of control. Summary 1.A study of atopic dermatitis in private practice in 100 consecutively encountered infants and children over a three-year period reveals equal distribution between sexes with onset in the first two years of life in 90 per cent. The dermatitis was exaggerated in the pollen seasons when due to pollen, and often in the fall to spring when due to foods, and at times to house dust and environmental allergens. Dermatitis was perennial in 67 per cent with exacerbation during the spring and summer in 28 per cent. 2.The majority of patients exhibited other allergic manifestations, and a family history of allergy was obtained in 65 per cent of cases. 3.Food, inhalant, drug, and infectant allergies were considered possible causes. Food and inhalant allergies proved to be most important. A detailed history, physical examination, and cautious skin testing by both scratch and intradermal methods were the most effective diagnostic procedures. Scratch or puncture testing with important ingestants and inhalants was performed on all patients, and intradermal testing reserved for those suspected of being inhalant sensitive, especially when environmental control alone was not effective. Intradermal testing was performed by our modification of the serial titration technique of Rinkel. 4.Elimination diets were used in 95 per cent of cases for study of suspected food allergy. Environmental control was instituted in 55 per cent, inhalant desensitization given in 58 per cent, and vaccine therapy for secondary infection in 10 per cent. Our recently devised filter tent was used for the study and treatment of inhalant allergy in 12 per cent. 5.Food allergy was the sole cause of atopic dermatitis in 44 per cent, and was associated with inhalant allergy in 41 per cent. Inhalant allergy alone was responsible in 15 per cent, and in association with food allergy in 41 per cent. The frequency of inhalant sensitivity increases after the first year. 6.The utilization of extremely weak dilutions of inhalant antigens is stressed. In the majority of inhalant sensitive individuals an appropriate initial desensitizing dose could be approximated by the serial dilution titration technique. However clinical titration alone was occasionally necessary. 7.The control of symptoms especially pruritus is discussed. 8.With study and treatment of specific causes, good or excellent results were obtained in 84 per cent of cases. These good results emphasize the importance of thorough and experienced study and treatment of inhalant allergy along with food allergy. In some cases the degree of relief at the end of the first year was only 50 to 75 per cent, and increased significantly during the second year of control." @default.
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• W2024923809 title "Atopic dermatitis in infants and children" @default.
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• W2024923809 doi "https://doi.org/10.1016/s0022-3476(51)80283-x" @default.
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