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• W2024930521 abstract "Urocortin 3 (Ucn 3) and various Ucn 3 fragments were tested with regard to antidepressive action in a modified forced swimming test following icv administration to mice. The fragment Ucn 3 (34-36) proved ineffective, whereas Ucn 3 (18-38), Ucn 3 (19-27), Ucn 3 (28-38), Ucn 3 (34-38), and Ucn 3 (36-38) demonstrated antidepressive-like action by shortening the immobility time and increasing the climbing and swimming times. The shortest molecule which elicited most of the antidepressive effects was the tripeptide Ucn 3 (36-38), H-Ala-Gln-Ile-NH(2). The results indicate that the total sequence of Ucn 3 is not necessary for the antidepressive action of Ucn 3. Furthermore, the antidepressant actions of Unc3 (19-27) and Ucn 3 (36-38) can be blocked by the CRF2 receptor antagonist Astressin 2β. Establishment of the smallest active sequence of the molecule may allow the synthesis of analogs or mimetics for antidepressive drugs." @default.
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• W2024930521 date "2011-04-01" @default.
• W2024930521 modified "2023-10-03" @default.
• W2024930521 title "Antidepressant-like effects of urocortin 3 fragments" @default.
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• W2024930521 doi "https://doi.org/10.1016/j.brainresbull.2011.01.016" @default.
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