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• W2024930891 abstract "Somatic cells can be reprogrammed to reach an embryonic stem cell-like state by overexpression of defined factors. Recent studies have greatly improved the efficiency of the reprogramming process but the underlying mechanisms regulating the transition from a somatic to a pluripotent state are still relatively unknown. MicroRNAs (miRs) are small noncoding RNAs that primarily regulate target gene expression post-transcriptionally. Here we present a systematic and comprehensive study of microRNAs in mouse embryonic fibroblasts (MEFs) during the early stage of cell fate decisions and reprogramming to a pluripotent state, in which significant transcriptional and epigenetic changes occur. One microRNA found to be highly induced during this stage of reprogramming, miR-135b, targeted the expression of extracellular matrix (ECM) genes including Wisp1 and Igfbp5. Wisp1 was shown to be a key regulator of additional ECM genes that serve as barriers to reprogramming. Regulation of Wisp 1 is likely mediated through biglycan, a glycoprotein highly expressed in MEFs that is silenced in reprogrammed cells. Collectively, this report reveals a novel link between microRNA-mediated regulation of ECM formation and somatic cell reprogramming, and demonstrates that microRNAs are powerful tools to dissect the intracellular and extracellular molecular mechanisms of reprogramming." @default.
• W2024930891 created "2016-06-24" @default.
• W2024930891 creator A5000058961 @default.
• W2024930891 creator A5005606848 @default.
• W2024930891 creator A5022854447 @default.
• W2024930891 creator A5031955104 @default.
• W2024930891 date "2014-10-21" @default.
• W2024930891 modified "2023-10-17" @default.
• W2024930891 title "MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming" @default.
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• W2024930891 doi "https://doi.org/10.1261/rna.043745.113" @default.
• W2024930891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4238355" @default.
• W2024930891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25336587" @default.
• W2024930891 hasPublicationYear "2014" @default.
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