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- W2024931432 abstract "See article by Mansaray et al. [5] (pages 359–366) in this issue. Interconnections between adjacent coronary arteries, known as “collateral vessels,” were discovered as early as the 17th century [1]. Anatomically, collaterals provide conduits through which blood can flow from normal to jeopardized myocardial regions, following obstruction of the antegrade blood supply. However, controversy has existed for decades about the true functional significance of the coronary collateral system. Native collateral vessels, consisting of thin walled vascular structures with a rudimentary smooth muscle coat, were thought for many years to be passive tubes through which blood flowed as a result of a mechanical pressure gradient between the normal and occluded vascular beds. The concept that native collaterals were capable of significant vasomotion, either dilatation or constriction, was not widely accepted.In recent years, however, a number of studies in different animal models have consistently demonstrated that collaterals dilate over the first several minutes following an acute coronary artery occlusion, resulting in a significant increase in blood flow. The mechanism for acute collateral enlargement, however, remains unknown. Collateral dilatation could potentially be mediated … * Tel.: +1-410-955-5997; fax: +1-410-955-0852 lbecker{at}welchlink.welch.jhu.edu" @default.
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- W2024931432 title "Constriction of native coronary collaterals" @default.
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- W2024931432 doi "https://doi.org/10.1016/s0008-6363(00)00128-0" @default.
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