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• W2024931618 startingPage "101" @default.
• W2024931618 abstract "Both stress and dysfunction of prefrontal cortex are linked to psychological disorders, and structure and function of medial prefrontal cortex (mPFC) are altered by stress. Chronic restraint stress causes dendritic retraction in the prelimbic region (PL) of mPFC in rats. Dopamine release in mPFC increases during stress, and chronic administration of dopaminergic agonists results in dendritic remodeling. Thus, stress-induced alterations in dopaminergic transmission in PL may contribute to dendritic remodeling. We examined the effects of dopamine D1 receptor (D1R) blockade in PL during daily restraint stress on dendritic morphology in PL. Rats either underwent daily restraint stress (3 h/day, 10 days) or remained unstressed. In each group, rats received daily infusions of either the D1R antagonist SCH23390 or vehicle into PL prior to restraint; unstressed and stressed rats that had not undergone surgery were also examined. On the final day of restraint, rats were euthanized and brains were processed for Golgi histology. Pyramidal neurons in PL were reconstructed and dendritic morphology was quantified. Vehicle-infused stressed rats demonstrated dendritic retraction compared to unstressed rats, and D1R blockade in PL prevented this effect. Moreover, in unstressed rats, D1R blockade produced dendritic retraction. These effects were not due to attenuation of the HPA axis response to acute stress: plasma corticosterone levels in a separate group of rats that underwent acute restraint stress with or without D1R blockade were not significantly different. These findings indicate that dopaminergic transmission in mPFC during stress contributes directly to the stress-induced retraction of apical dendrites, while dopamine transmission in the absence of stress is important in maintaining normal dendritic morphology." @default.
• W2024931618 created "2016-06-24" @default.
• W2024931618 creator A5024077621 @default.
• W2024931618 creator A5031581902 @default.
• W2024931618 creator A5043525869 @default.
• W2024931618 creator A5069323059 @default.
• W2024931618 date "2015-01-01" @default.
• W2024931618 modified "2023-09-25" @default.
• W2024931618 title "D1 receptors regulate dendritic morphology in normal and stressed prelimbic cortex" @default.
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• W2024931618 doi "https://doi.org/10.1016/j.psyneuen.2014.09.020" @default.
• W2024931618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4268137" @default.
• W2024931618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25305546" @default.
• W2024931618 hasPublicationYear "2015" @default.
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