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• W2024932046 abstract "Teeth and their tissues, dentin and enamel, have a long, well-defined history. Their origin was traced back to the extra-oral dermal skeleton of early jawless vertebrates, approximately 500 million years ago, mya (see reviews in Huysseune and Sire, 1998; Smith and Coates, 2000; Sire and Huysseune, 2003). Once recruited into the mouth in early gnathostomes, circa 450 mya, teeth were subjected to strong selective pressure due to their crucial function. This explains why teeth, and particularly their developmental processes, organization and structural components, were conserved nearly unchanged through geological times. In mammals, as in most tetrapod taxa, teeth are covered by a thick and highly mineralized, protective tissue, enamel. The amelogenin gene (AMEL) encodes the major protein of enamel (90% of the organic matrix). Recent molecular analyses have brought insights into the evolutionary pattern of AMEL in mammals (Delgado et al. 2005) and have shown that the history of this protein could have started by the end of the Precambrian period (Sire et al., 2007). Comparative studies of AMEL in mammals, reptiles and amphibians have revealed highly conserved residues located at the Cand N-terminal regions and have indicated that a large part of the hydrophobic, central region of the molecule, encoded by the largest exon 6, was more variable (Ishiyama et al., 1998; Toyosawa et al., 1998; Delgado et al., 2005). Because AMEL is Xlinked in many mammal lineages, the gene as a whole is" @default.
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• W2024932046 date "2008-05-01" @default.
• W2024932046 modified "2023-10-18" @default.
• W2024932046 title "Amelogenin, the major protein of tooth enamel: A new phylogenetic marker for ordinal mammal relationships" @default.
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• W2024932046 doi "https://doi.org/10.1016/j.ympev.2008.01.025" @default.
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