Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024932297> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2024932297 abstract "Since the first description of cellular autofluorescence over a century ago, we have now come to appreciate that autofluorescence should not be discarded as a biological artifact but embraced as a biological phenomenon with potentially important cellular relevance. Indeed, cellular and tissue autofluorescence has been attributed to a spectrum of unrelated molecules such as porphyrins, vitamins (vitamin A, riboflavin, thiamine), structural proteins, lipofuscin and ceroid pigments. We have recently shown that freshly isolated epithelial cancer stem cells (CSCs) bear autofluorescent vesicles in the cytoplasm. Our studies definitively prove that riboflavin and not lipofuscin is the source of autofluorescence in CSCs as the inhibition of ATP and not autophagy eliminates CSC autofluorescence, that the ATP-dependent transporter ABCG2, for which riboflavin is a substrate, is overexpressed in autofluorescent CSCs and co-localizes with the membrane of intracellular autofluorescent vesicles, the ABCG2-specific inhibitor Fumitremorgin C reversibly eliminates CSC autofluorescence, riboflavin is a substrate for ABCG2, and only the addition of riboflavin to vitamin-deprived CSC cultures is capable of restoring autofluorescence. Thus, the sum of these data unequivocally supports the conclusion that the source of CSC autofluorescence is the vitamin riboflavin." @default.
- W2024932297 created "2016-06-24" @default.
- W2024932297 creator A5018016887 @default.
- W2024932297 creator A5031406092 @default.
- W2024932297 creator A5058816620 @default.
- W2024932297 date "2015-03-12" @default.
- W2024932297 modified "2023-10-18" @default.
- W2024932297 title "The fuss over lipo“fussâ€cin: not all autofluorescence is the same" @default.
- W2024932297 cites W1546135534 @default.
- W2024932297 cites W2029570717 @default.
- W2024932297 cites W2039035664 @default.
- W2024932297 cites W2055902281 @default.
- W2024932297 cites W2058187222 @default.
- W2024932297 cites W2065941404 @default.
- W2024932297 cites W2080426159 @default.
- W2024932297 cites W2123951949 @default.
- W2024932297 cites W28856689 @default.
- W2024932297 cites W4231756003 @default.
- W2024932297 doi "https://doi.org/10.4081/ejh.2015.2512" @default.
- W2024932297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4378222" @default.
- W2024932297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25820568" @default.
- W2024932297 hasPublicationYear "2015" @default.
- W2024932297 type Work @default.
- W2024932297 sameAs 2024932297 @default.
- W2024932297 citedByCount "11" @default.
- W2024932297 countsByYear W20249322972015 @default.
- W2024932297 countsByYear W20249322972016 @default.
- W2024932297 countsByYear W20249322972017 @default.
- W2024932297 countsByYear W20249322972018 @default.
- W2024932297 countsByYear W20249322972019 @default.
- W2024932297 countsByYear W20249322972023 @default.
- W2024932297 crossrefType "journal-article" @default.
- W2024932297 hasAuthorship W2024932297A5018016887 @default.
- W2024932297 hasAuthorship W2024932297A5031406092 @default.
- W2024932297 hasAuthorship W2024932297A5058816620 @default.
- W2024932297 hasBestOaLocation W20249322971 @default.
- W2024932297 hasConcept C104317684 @default.
- W2024932297 hasConcept C121332964 @default.
- W2024932297 hasConcept C149011108 @default.
- W2024932297 hasConcept C179687394 @default.
- W2024932297 hasConcept C185592680 @default.
- W2024932297 hasConcept C186198217 @default.
- W2024932297 hasConcept C190062978 @default.
- W2024932297 hasConcept C2776155809 @default.
- W2024932297 hasConcept C44312359 @default.
- W2024932297 hasConcept C512196 @default.
- W2024932297 hasConcept C55493867 @default.
- W2024932297 hasConcept C62520636 @default.
- W2024932297 hasConcept C86803240 @default.
- W2024932297 hasConcept C91881484 @default.
- W2024932297 hasConcept C95444343 @default.
- W2024932297 hasConceptScore W2024932297C104317684 @default.
- W2024932297 hasConceptScore W2024932297C121332964 @default.
- W2024932297 hasConceptScore W2024932297C149011108 @default.
- W2024932297 hasConceptScore W2024932297C179687394 @default.
- W2024932297 hasConceptScore W2024932297C185592680 @default.
- W2024932297 hasConceptScore W2024932297C186198217 @default.
- W2024932297 hasConceptScore W2024932297C190062978 @default.
- W2024932297 hasConceptScore W2024932297C2776155809 @default.
- W2024932297 hasConceptScore W2024932297C44312359 @default.
- W2024932297 hasConceptScore W2024932297C512196 @default.
- W2024932297 hasConceptScore W2024932297C55493867 @default.
- W2024932297 hasConceptScore W2024932297C62520636 @default.
- W2024932297 hasConceptScore W2024932297C86803240 @default.
- W2024932297 hasConceptScore W2024932297C91881484 @default.
- W2024932297 hasConceptScore W2024932297C95444343 @default.
- W2024932297 hasIssue "1" @default.
- W2024932297 hasLocation W20249322971 @default.
- W2024932297 hasLocation W20249322972 @default.
- W2024932297 hasLocation W20249322973 @default.
- W2024932297 hasLocation W20249322974 @default.
- W2024932297 hasLocation W20249322975 @default.
- W2024932297 hasOpenAccess W2024932297 @default.
- W2024932297 hasPrimaryLocation W20249322971 @default.
- W2024932297 hasRelatedWork W2003179114 @default.
- W2024932297 hasRelatedWork W2013556471 @default.
- W2024932297 hasRelatedWork W2024932297 @default.
- W2024932297 hasRelatedWork W2056483122 @default.
- W2024932297 hasRelatedWork W2087688547 @default.
- W2024932297 hasRelatedWork W2126931030 @default.
- W2024932297 hasRelatedWork W2132376565 @default.
- W2024932297 hasRelatedWork W3197541161 @default.
- W2024932297 hasRelatedWork W4200373596 @default.
- W2024932297 hasRelatedWork W932205418 @default.
- W2024932297 hasVolume "59" @default.
- W2024932297 isParatext "false" @default.
- W2024932297 isRetracted "false" @default.
- W2024932297 magId "2024932297" @default.
- W2024932297 workType "article" @default.