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• W2024933023 abstract "Differential gene expression in CD3 + T cells from allergic patients stimulated with allergen will provide important information on the responses of T cells. After stimulation of peripheral blood mononuclear cells (PBMCs) with mite extracts, levels of gene transcription were examined in CD3 + T cells from allergic patients. Stimulation of PBMCs from mite specific IgE positive subjects resulted in specific upregulation of MAL transcription levels that was mediated by IL-4 secretion. The MAL protein in IL-4 stimulated primary T cells preferentially localized in glycolipid-enriched membrane (GEM) microdomains. When MAL was exogenously expressed in primary T cells, CD3ζ was concomitantly enriched, along with the expression of MAL, in GEM microdomains. GEMs are important for the formation and stabilization of TCR signaling complexes. Therefore, MAL may play a role in the formation of GEMs in activated T cells and the high expression of MAL may contribute to Th2 immune response." @default.
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• W2024933023 date "2005-01-01" @default.
• W2024933023 modified "2023-09-25" @default.
• W2024933023 title "Mite-antigen Stimulates MAL Expression in Peripheral Blood T Cells of Mite-sensitive Subjects" @default.
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• W2024933023 doi "https://doi.org/10.2332/allergolint.54.273" @default.
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