Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024935436> ?p ?o ?g. }
- W2024935436 endingPage "e77829" @default.
- W2024935436 startingPage "e77829" @default.
- W2024935436 abstract "miRNAs regulate gene expression and are key mediators of tumourigenesis. miR-129 has diverse effects in tumours, but its role in laryngeal squamous cell carcinoma (LSCC) remains unknown. This article focuses on the role of miR-129-5p in LSCC. We show miR-129-5p is upregulated in primary LSCC tumours and correlated with advanced disease. Down-regulating miR-129-5p suppressed cell proliferation and migration, and caused cell cycle arrest in Hep-2 cell lines. Downregulation of miR-129-5p alone is sufficient to induce apoptosis both in vivo and in vitro. Moreover, the growth of LSCC xenograft exposed to miR-129-5p antisense oligonucleotides (ASO) in BALB/c mice was markedly inhibited. In addition, we found that miR-129-5p targeted adenomatous polyposis coli (APC) to release inhibition of Wnt signalling causing cell growth and tumourigenesis. Our results suggest miR-129-5p functions as an oncogene in LSCC by repressing APC and is a potential therapeutic target for LSCC." @default.
- W2024935436 created "2016-06-24" @default.
- W2024935436 creator A5006319126 @default.
- W2024935436 creator A5007672178 @default.
- W2024935436 creator A5016894561 @default.
- W2024935436 creator A5017250084 @default.
- W2024935436 creator A5021541643 @default.
- W2024935436 creator A5022076048 @default.
- W2024935436 creator A5037067067 @default.
- W2024935436 creator A5053275663 @default.
- W2024935436 creator A5062844498 @default.
- W2024935436 creator A5073759462 @default.
- W2024935436 date "2013-10-23" @default.
- W2024935436 modified "2023-09-25" @default.
- W2024935436 title "Down-Regulation of miR-129-5p Inhibits Growth and Induces Apoptosis in Laryngeal Squamous Cell Carcinoma by Targeting APC" @default.
- W2024935436 cites W144423133 @default.
- W2024935436 cites W1977377125 @default.
- W2024935436 cites W1984374221 @default.
- W2024935436 cites W1992106366 @default.
- W2024935436 cites W1997202844 @default.
- W2024935436 cites W2011607173 @default.
- W2024935436 cites W2014610388 @default.
- W2024935436 cites W2014900267 @default.
- W2024935436 cites W2014946489 @default.
- W2024935436 cites W2021536610 @default.
- W2024935436 cites W2032578973 @default.
- W2024935436 cites W2049230518 @default.
- W2024935436 cites W2066307520 @default.
- W2024935436 cites W2067588941 @default.
- W2024935436 cites W2073620078 @default.
- W2024935436 cites W2075465108 @default.
- W2024935436 cites W2081379168 @default.
- W2024935436 cites W2084120869 @default.
- W2024935436 cites W2089655089 @default.
- W2024935436 cites W2092516691 @default.
- W2024935436 cites W2097689792 @default.
- W2024935436 cites W2100481402 @default.
- W2024935436 cites W2100651747 @default.
- W2024935436 cites W2107405721 @default.
- W2024935436 cites W2116431617 @default.
- W2024935436 cites W2131811102 @default.
- W2024935436 cites W2139908319 @default.
- W2024935436 cites W2156839972 @default.
- W2024935436 cites W2158812368 @default.
- W2024935436 cites W2163587546 @default.
- W2024935436 cites W2170306230 @default.
- W2024935436 cites W2171296186 @default.
- W2024935436 cites W3023299375 @default.
- W2024935436 cites W3146360245 @default.
- W2024935436 doi "https://doi.org/10.1371/journal.pone.0077829" @default.
- W2024935436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3806837" @default.
- W2024935436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24194897" @default.
- W2024935436 hasPublicationYear "2013" @default.
- W2024935436 type Work @default.
- W2024935436 sameAs 2024935436 @default.
- W2024935436 citedByCount "66" @default.
- W2024935436 countsByYear W20249354362014 @default.
- W2024935436 countsByYear W20249354362015 @default.
- W2024935436 countsByYear W20249354362016 @default.
- W2024935436 countsByYear W20249354362017 @default.
- W2024935436 countsByYear W20249354362018 @default.
- W2024935436 countsByYear W20249354362019 @default.
- W2024935436 countsByYear W20249354362020 @default.
- W2024935436 countsByYear W20249354362021 @default.
- W2024935436 countsByYear W20249354362022 @default.
- W2024935436 countsByYear W20249354362023 @default.
- W2024935436 crossrefType "journal-article" @default.
- W2024935436 hasAuthorship W2024935436A5006319126 @default.
- W2024935436 hasAuthorship W2024935436A5007672178 @default.
- W2024935436 hasAuthorship W2024935436A5016894561 @default.
- W2024935436 hasAuthorship W2024935436A5017250084 @default.
- W2024935436 hasAuthorship W2024935436A5021541643 @default.
- W2024935436 hasAuthorship W2024935436A5022076048 @default.
- W2024935436 hasAuthorship W2024935436A5037067067 @default.
- W2024935436 hasAuthorship W2024935436A5053275663 @default.
- W2024935436 hasAuthorship W2024935436A5062844498 @default.
- W2024935436 hasAuthorship W2024935436A5073759462 @default.
- W2024935436 hasBestOaLocation W20249354361 @default.
- W2024935436 hasConcept C104317684 @default.
- W2024935436 hasConcept C121608353 @default.
- W2024935436 hasConcept C127561419 @default.
- W2024935436 hasConcept C137620995 @default.
- W2024935436 hasConcept C145059251 @default.
- W2024935436 hasConcept C1491633281 @default.
- W2024935436 hasConcept C185592680 @default.
- W2024935436 hasConcept C190283241 @default.
- W2024935436 hasConcept C2778237340 @default.
- W2024935436 hasConcept C2781018059 @default.
- W2024935436 hasConcept C29537977 @default.
- W2024935436 hasConcept C502942594 @default.
- W2024935436 hasConcept C526805850 @default.
- W2024935436 hasConcept C54355233 @default.
- W2024935436 hasConcept C62112901 @default.
- W2024935436 hasConcept C62478195 @default.
- W2024935436 hasConcept C86803240 @default.
- W2024935436 hasConcept C95444343 @default.
- W2024935436 hasConceptScore W2024935436C104317684 @default.
- W2024935436 hasConceptScore W2024935436C121608353 @default.