FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024943614> ?p ?o ?g. }

• W2024943614 endingPage "e5368" @default.
• W2024943614 startingPage "e5368" @default.
• W2024943614 abstract "Backgound Brucella melitensis is a facultative, intracellular, pathogenic bacterium that replicates within macrophages. The type IV secretion system encoded by the virB operon (virB) is involved in Brucella intracellular survival. However, the underlying molecular mechanisms, especially the target proteins affected by the virB, remain largely unclear. Methodology/Principal Findings In order to define the proteins affected by virB, the proteomes of wild-type and the virB mutant were compared under in vitro conditions where virB was highly activated. The differentially expressed proteins were identified by MALDI-TOF-MS. Forty-four down-regulated and eighteen up-regulated proteins which exhibited a 2-fold or greater change were identified. These proteins included those involved in amino acid transport and metabolism, lipid metabolism, energy production, cell membrane biogenesis, translation, post-translational modifications and protein turnover, as well as unknown proteins. Interestingly, several important virulence related proteins involved in intracellular survival, including VjbR, DnaK, HtrA, Omp25, and GntR, were down-regulated in the virB mutant. Transcription analysis of virB and vjbR at different growth phase showed that virB positively affect transcription of vjbR in a growth phase dependent manner. Quantitative RT-PCR showed that transcription of these genes was also affected by virB during macrophage cell infection, consistent with the observed decreased survival of the virB mutant in macrophage. Conclusions/Significance These data indicated that the virB operon may control the intracellular survival of Brucella by affecting the expression of relevant proteins." @default.
• W2024943614 created "2016-06-24" @default.
• W2024943614 creator A5006101590 @default.
• W2024943614 creator A5006428200 @default.
• W2024943614 creator A5008033409 @default.
• W2024943614 creator A5023968524 @default.
• W2024943614 creator A5026104846 @default.
• W2024943614 creator A5030708251 @default.
• W2024943614 creator A5039031537 @default.
• W2024943614 creator A5044282595 @default.
• W2024943614 creator A5044702979 @default.
• W2024943614 creator A5045787470 @default.
• W2024943614 creator A5046584963 @default.
• W2024943614 creator A5054425915 @default.
• W2024943614 creator A5062515774 @default.
• W2024943614 creator A5070938095 @default.
• W2024943614 creator A5085740866 @default.
• W2024943614 creator A5086003163 @default.
• W2024943614 date "2009-04-29" @default.
• W2024943614 modified "2023-10-16" @default.
• W2024943614 title "Comparative Proteomics Analyses Reveal the virB of B. melitensis Affects Expression of Intracellular Survival Related Proteins" @default.
• W2024943614 cites W1564628427 @default.
• W2024943614 cites W1674535886 @default.
• W2024943614 cites W1791713121 @default.
• W2024943614 cites W1920928767 @default.
• W2024943614 cites W1967111256 @default.
• W2024943614 cites W1993292062 @default.
• W2024943614 cites W2005709155 @default.
• W2024943614 cites W2015649802 @default.
• W2024943614 cites W2016151173 @default.
• W2024943614 cites W2018635122 @default.
• W2024943614 cites W2051662925 @default.
• W2024943614 cites W2056573022 @default.
• W2024943614 cites W2058111600 @default.
• W2024943614 cites W2059939400 @default.
• W2024943614 cites W2083742560 @default.
• W2024943614 cites W2090425916 @default.
• W2024943614 cites W2093431241 @default.
• W2024943614 cites W2098259424 @default.
• W2024943614 cites W2098478833 @default.
• W2024943614 cites W2100185037 @default.
• W2024943614 cites W2103718004 @default.
• W2024943614 cites W2103779466 @default.
• W2024943614 cites W2107277218 @default.
• W2024943614 cites W2107975078 @default.
• W2024943614 cites W2111200178 @default.
• W2024943614 cites W2111443728 @default.
• W2024943614 cites W2114088731 @default.
• W2024943614 cites W2117075356 @default.
• W2024943614 cites W2122003237 @default.
• W2024943614 cites W2127845652 @default.
• W2024943614 cites W2128698173 @default.
• W2024943614 cites W2129265002 @default.
• W2024943614 cites W2130338905 @default.
• W2024943614 cites W2132432780 @default.
• W2024943614 cites W2143711863 @default.
• W2024943614 cites W2153740616 @default.
• W2024943614 cites W2153767036 @default.
• W2024943614 cites W2164779455 @default.
• W2024943614 cites W2347230326 @default.
• W2024943614 doi "https://doi.org/10.1371/journal.pone.0005368" @default.
• W2024943614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670520" @default.
• W2024943614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19401764" @default.
• W2024943614 hasPublicationYear "2009" @default.
• W2024943614 type Work @default.
• W2024943614 sameAs 2024943614 @default.
• W2024943614 citedByCount "41" @default.
• W2024943614 countsByYear W20249436142012 @default.
• W2024943614 countsByYear W20249436142013 @default.
• W2024943614 countsByYear W20249436142014 @default.
• W2024943614 countsByYear W20249436142015 @default.
• W2024943614 countsByYear W20249436142016 @default.
• W2024943614 countsByYear W20249436142017 @default.
• W2024943614 countsByYear W20249436142019 @default.
• W2024943614 countsByYear W20249436142020 @default.
• W2024943614 countsByYear W20249436142022 @default.
• W2024943614 crossrefType "journal-article" @default.
• W2024943614 hasAuthorship W2024943614A5006101590 @default.
• W2024943614 hasAuthorship W2024943614A5006428200 @default.
• W2024943614 hasAuthorship W2024943614A5008033409 @default.
• W2024943614 hasAuthorship W2024943614A5023968524 @default.
• W2024943614 hasAuthorship W2024943614A5026104846 @default.
• W2024943614 hasAuthorship W2024943614A5030708251 @default.
• W2024943614 hasAuthorship W2024943614A5039031537 @default.
• W2024943614 hasAuthorship W2024943614A5044282595 @default.
• W2024943614 hasAuthorship W2024943614A5044702979 @default.
• W2024943614 hasAuthorship W2024943614A5045787470 @default.
• W2024943614 hasAuthorship W2024943614A5046584963 @default.
• W2024943614 hasAuthorship W2024943614A5054425915 @default.
• W2024943614 hasAuthorship W2024943614A5062515774 @default.
• W2024943614 hasAuthorship W2024943614A5070938095 @default.
• W2024943614 hasAuthorship W2024943614A5085740866 @default.
• W2024943614 hasAuthorship W2024943614A5086003163 @default.
• W2024943614 hasBestOaLocation W20249436141 @default.
• W2024943614 hasConcept C104317684 @default.
• W2024943614 hasConcept C104397665 @default.
• W2024943614 hasConcept C138885662 @default.
• W2024943614 hasConcept C143065580 @default.

• next