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- W2024944907 abstract "Acquisition of a mature pattern of gonadotropin-releasing hormone (GnRH) secretion from the CNS is a hallmark of the pubertal process. Little is known about GnRH release during sexual maturation, but it is assumed to be minimal before later stages of puberty. We studied spontaneous GnRH secretion in brain slices from male mice during perinatal and postnatal development using fast-scan cyclic voltammetry (FSCV) to detect directly the oxidation of secreted GnRH. There was good correspondence between the frequency of GnRH release detected by FSCV in the median eminence of slices from adults with previous reports of in vivo luteinizing hormone (LH) pulse frequency. The frequency of GnRH release in the late embryonic stage was surprisingly high, reaching a maximum in newborns and remaining elevated in 1-week-old animals despite low LH levels. Early high-frequency GnRH release was similar in wild-type and kisspeptin knock-out mice indicating that this release is independent of kisspeptin-mediated excitation. In vivo treatment with testosterone or in vitro treatment with gonadotropin-inhibitory hormone (GnIH) reduced GnRH release frequency in slices from 1-week-old mice. RF9, a putative GnIH antagonist, restored GnRH release in slices from testosterone-treated mice, suggesting that testosterone inhibition may be GnIH-dependent. At 2-3 weeks, GnRH release is suppressed before attaining adult patterns. Reduction in early life spontaneous GnRH release frequency coincides with the onset of the ability of exogenous GnRH to induce pituitary LH secretion. These findings suggest that lack of pituitary secretory response, not lack of GnRH release, initially blocks downstream activation of the reproductive system." @default.
- W2024944907 created "2016-06-24" @default.
- W2024944907 creator A5016026250 @default.
- W2024944907 creator A5026534917 @default.
- W2024944907 creator A5046303021 @default.
- W2024944907 date "2014-11-05" @default.
- W2024944907 modified "2023-09-27" @default.
- W2024944907 title "Development of Gonadotropin-Releasing Hormone Secretion and Pituitary Response" @default.
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- W2024944907 doi "https://doi.org/10.1523/jneurosci.2200-14.2014" @default.
- W2024944907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4220034" @default.
- W2024944907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25378170" @default.
- W2024944907 hasPublicationYear "2014" @default.
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